{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:07:52Z","timestamp":1783044472383,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7068,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have studied the electrophsiological effects of IgG obtained from four patients with Lambert\u2010Eaton myasthenic syndrome (LEMS) (two with small cell carcinoma), using the mouse passive transfer model. Mice received LEMS or control IgG or plasma, 10 to 60 mg daily. Microeletrode intracellular recordings were from diaphragm muscle. LEMS IgG and plasma decreased end\u2010plate potential quantal content similarly, confirming IgG as the active factor. LEMS IgG was equally effective C5\u2010deficient mice, indicating that late complement components are not required. The time course of decline and recovery of quantal content closely followed that of the human IgG in the mouse serum, with time to half\u2010maximal effect of about 1.5 days in each case. Binding\/dissociation of IgG or down\/up regulation of the antigenic determinants, possibly Ca<jats:sup>2+<\/jats:sup> channels, has a half\u2010life of between 2 and 36 hours. The results confirm our concepts that IgG antibody to nerve terminal determinants underlies the disorder of transmitter release in LEMS.<\/jats:p>","DOI":"10.1002\/ana.410170610","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:23:15Z","timestamp":1104600195000},"page":"587-592","source":"Crossref","is-referenced-by-count":64,"title":["Action of Lambert\u2010Eaton myasthenic syndrome IgG at mouse motor nerve 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