{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:03Z","timestamp":1790355723931,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have studied 12 patients with diffuse hemorrhagic cerebral amyloid angiopathy clinically and at postmortem examination. The brains in 8 patients had diffuse bilateral loss of myelin in the hemispheric white matter sparing the U fibers, corpus callosum, and internal capsules. The periventricular areas were predominantly affected. Microscopic examination of the white matter showed an association with subacute or chronic edematous lesions: spongiosis, swollen oligodendroglia, widening of the perivascular spaces with edema fluid or siderophages, hyalinization of the blood vessel walls, incomplete myelin loss, and astrocytic gliosis. Three of 8 autopsied patients had undergone computed tomographic examination, which showed bilateral hypodensity of the hemispheric white matter. The brains of 4 patients with illnesses of shorter duration showed only discrete but similar lesions in the centrum semiovale. These white matter changes are similar to those observed in Binswanger's subcortical encephalopathy. We suggest that a common mechanism of hypoperfusion of the distal white matter causes the leukoencephalopathy.<\/jats:p>","DOI":"10.1002\/ana.410180110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:23:46Z","timestamp":1104600226000},"page":"54-59","source":"Crossref","is-referenced-by-count":187,"title":["Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"18","author":[{"given":"F.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dubas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roullet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Escourolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.12.1206"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.9.920"},{"key":"e_1_2_1_4_2","first-page":"93","article-title":"Leucoenc\u00e9phalopathies art\u00e9riopathiques. 17 observations anatomo\u2010cliniques","volume":"141","author":"Dubas F","year":"1985","journal-title":"Rev Neurol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050150112027"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.6.730"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.141.3.7302224"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470719749.ch8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(81)92217-0","article-title":"Binswanger's encephalopathy","volume":"1","author":"Janota I","year":"1981","journal-title":"Lancet"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00352748"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010621"},{"issue":"12","key":"e_1_2_1_12_2","first-page":"763","article-title":"H\u00e9morragie c\u00e9r\u00e9brale r\u00e9cidivante et angiopathie amylo\u00efde","volume":"139","author":"Julien J","year":"1983","journal-title":"Rev Neurol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160308"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.2.120"},{"key":"e_1_2_1_15_2","first-page":"111","article-title":"Maladie de Binswanger et formes apparent\u00e9es","volume":"118","author":"Mikol J","year":"1968","journal-title":"Rev Neurol"},{"key":"e_1_2_1_16_2","first-page":"22","article-title":"Clinicopathologic studies of primary cerebral amyloid angiopathy","volume":"54","author":"Okazaki H","year":"1979","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_17_2","first-page":"359","article-title":"Subcortical arteriosclerotic encephalopathy","volume":"3","author":"Olszewski J","year":"1962","journal-title":"World Neurol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890989"},{"key":"e_1_2_1_19_2","volume-title":"Amyloidosis: Cause and Manifestation of Senile Deterioration","author":"Schwartz P","year":"1970"},{"key":"e_1_2_1_20_2","first-page":"200","volume-title":"Cerebral Vascular Disease","author":"Seitelberger F","year":"1974"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1981.tb01757.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198012000-00015"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316143"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198405000-00079"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410180110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410180110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:25:13Z","timestamp":1697819113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410180110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1002\/ana.410180110"],"URL":"https:\/\/doi.org\/10.1002\/ana.410180110","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}