{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:23:34Z","timestamp":1757705014116},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6796,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010chain polyisoprenol alcohol (dolichols) levels are significantly increased in the urinary sediment of patients with infantile, late\u2010infantile, and juvenile forms of neuronal ceroid\u2010lipofuscinosis (NCL). The values in obligate heterozy\u2010gotes for these diseases are similar to those in patients with other neurological diseases and in healthy controls. Antioxidant treatment of patients with juvenile NCL has no effect on dolichol values. The rate of false\u2010negative results is 13.9% in infantile, 7.5% in late\u2010infantile, and 15.0% in juvenile NCL. False\u2010positive results were found in 8.2 to 14.3% of patients with other neurological diseases and in 15.4% of healthy controls. The test is of considerable value in the diagnosis of NCL and in decisions on whether to perform a biopsy. It is not useful in the screening of random samples, however.<\/jats:p>","DOI":"10.1002\/ana.410190308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:30:00Z","timestamp":1104600600000},"page":"270-274","source":"Crossref","is-referenced-by-count":42,"title":["Urinary sediment dolichols in the diagnosis of neuronal ceroid\u2010lipofuscinosis"],"prefix":"10.1002","volume":"19","author":[{"given":"Leonhard S.","family":"Wolfe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Palo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkko","family":"Santavuori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Andermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Andermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob C.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Kolodny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197506262922620"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198502000-00014"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/100.1.137"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb13592.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198207000-00007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1985.tb05044.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80034-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1985.tb03178.x"},{"key":"e_1_2_1_10_2","first-page":"832","article-title":"Increased urinary dolichol in newborns whose mothers were heavy alcohol users","volume":"14","author":"Wisniewski KE","year":"1983","journal-title":"Ann Neurol"},{"key":"e_1_2_1_11_2","first-page":"297","article-title":"Fusion of lysosomes to normal and batten disease fibroblasts","volume":"16","author":"Wolfe LS","year":"1985","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_12_2","first-page":"315","volume-title":"Lysosomes and Lysosomal Storage Diseases","author":"Wolfe LS","year":"1981"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.841336"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.1.103"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1016\/S0021-9258(20)65188-2","article-title":"The site of biosynthesis and intracellular deposition of dolichol in rat liver","volume":"257","author":"Wong TK","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_2","first-page":"588","volume-title":"Handbook of Clinical Neurology","author":"Zeman W","year":"1970"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410190308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410190308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:07:58Z","timestamp":1697850478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410190308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1002\/ana.410190308"],"URL":"https:\/\/doi.org\/10.1002\/ana.410190308","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}