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The relationship between the age of the patient, duration of the disease, and duration of L\u2010dopa therapy versus density of brain D<jats:sub>2<\/jats:sub> dopamine receptors was examined using [<jats:sup>3<\/jats:sup>H]spiperone. Receptor density in parkinsonian tissues was constant over the age range of 56 to 90 years, as was the case for control tissues. Density did not change with duration of disease up to 24 years. Treatment with L\u2010dopa did not cause progressive reduction in receptor density. The diminished clinical response in the final stages of Parkinson's disease is not due to receptor dropout, and must depend on other factors.<\/jats:p>","DOI":"10.1002\/ana.410190510","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:31:14Z","timestamp":1104600674000},"page":"487-492","source":"Crossref","is-referenced-by-count":82,"title":["Dopamine D<sub>2<\/sub> receptor density remains constant in treated Parkinson's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Mark","family":"Guttman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Seeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Riederer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Jellinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wallace W.","family":"Tourtellotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"94","volume-title":"Parkinson's Disease","author":"Birkmayer W","year":"1983"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90238-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040619"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90271-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S0317167100046412","article-title":"Should levodopa therapy for parkinsonism be started early or late? 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