{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:46:55Z","timestamp":1784296015326,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6704,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient with mitochondrial myopathy due to complex III deficiency who was treated with vitamin K<jats:sub>3<\/jats:sub> (menadiol sodium diphosphate, 40 mg daily) and vitamin C showed clinical improvement. A 1\u2010year study with phosphorus 31 nuclear magnetic resonance (<jats:sup>31<\/jats:sup>P\u2010NMR) monitoring has shown that (1) clinical and metabolic improvement was maintained by this therapy; (2) increasing the dose of vitamin K<jats:sub>3<\/jats:sub> to 80 mg daily improved the bioenergetic state of the patient's muscles at rest; (3) postexercise recovery was less responsive to the increased dose; and (4) a higher dose of vitamin K<jats:sub>3<\/jats:sub> (80 mg\/day) did not produce side effects. The differential therapeutic effects of vitamin K<jats:sub>3<\/jats:sub> at rest and during exercise recovery are probably due to the differential kinetics of each metabolic state. Monitoring muscle bioenergetics with <jats:sup>31<\/jats:sup>P\u2010NMR is valuable in documenting therapeutic improvements in mitochondrial myopathies.<\/jats:p>","DOI":"10.1002\/ana.410190615","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:31:48Z","timestamp":1104600708000},"page":"598-602","source":"Crossref","is-referenced-by-count":101,"title":["Treatment of mitochondrial myopathy due to complex III deficiency with vitamins K<sub>3<\/sub> and C: A <sup>31<\/sup>P\u2010NMR follow\u2010up study"],"prefix":"10.1002","volume":"19","author":[{"given":"Zohar","family":"Argov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Bank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Maris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Eleff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy G.","family":"Kennaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton","family":"Chance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"ArnoldDL BorePJ RaddaGK et al: Excessive acidosis of skeletal muscle on exercise in the post viral exhaustion\/fatigue syndrome: a31P\u2010NMR study. 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