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All patients with clinically active MS have elevated levels of total anti\u2010MBP, which may be present in either free or bound form. Patients whose disease is in remission have undetectable anti\u2010MBP levels, and some patients with clinically stable disease with residual disability may have detectable antibody titers. Chronically progressive MS is usually associated with high levels of antibody in the bound rather than the free form, resulting in a low or normal free\/bound ratio. In contrast, MS exacerbations are characterized by relatively high levels of free anti\u2010MBP in the cerebrospinal fluid, resulting in a high free\/bound antibody ratio. Bound anti\u2010MBP was also detected in elevated levels in 1 patient with subacute sclerosing panencephalitis and 2 of 8 patients with postinfectious encephalomyelitis. Although elevated levels of cerebrospinal fluid anti\u2010MBP are not specific for MS, they are strongly associated with disease activity and may be involved in the pathogenesis of demyelination in patients with MS.<\/jats:p>","DOI":"10.1002\/ana.410200105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:32:11Z","timestamp":1104600731000},"page":"20-25","source":"Crossref","is-referenced-by-count":60,"title":["Diagnostic value of cerebrospinal fluid anti\u2013myelin basic protein in patients with multiple sclerosis"],"prefix":"10.1002","volume":"20","author":[{"given":"Kenneth G.","family":"Warren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Catz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972204"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27855"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.4049\/jimmunol.124.5.2324","article-title":"Identification of a unique idiotype in cerebrospinal fluid and serum of a patient with multiple sclerosis","volume":"124","author":"Baird LG","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.1.24"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080104"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197612232952604"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.3.429"},{"issue":"4","key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S0317167100045078","article-title":"Myelin basic protein: a component of circulating immune complexes in multiple sclerosis","volume":"10","author":"Dasgupta MK","year":"1983","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb03151.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(48)90389-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/00365517709091498","article-title":"Principles of albumin and IgG analyses in neurological diseases. 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