{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:33:46Z","timestamp":1784691226068,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonidine has been suggested to be effective in Gilles de la Tourette's syndrome (GTS), but no double\u2010blind study has ever evaluated its effects using objective measures. Thirty patients with GTS completed a 6\u2010month placebo\u2010controlled crossover study of the effectiveness of clonidine. Videotapes were obtained at each 3\u2010week visit and were evaluated randomly at the end of the study for distribution, frequency, and severity of motor and vocal tics. Quantifiable psychometric examinations were performed as well. The use of clonidine did not significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) reduce motor tics, vocalizations, or behavior. The effect of a low dose (0.0075 mg\/kg\/day) was no different from that of a high dose (0.015 mg\/kg\/day); children's responses were no different from adults'; and those also receiving neuroleptic agents showed the same lack of efficacy as seen in patients on no other medication. Dosing schedule did not affect the objective ratings; scores from clonidine given twice a day were equivalent to those for three times a day.<\/jats:p>","DOI":"10.1002\/ana.410210313","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:41:27Z","timestamp":1104601287000},"page":"307-310","source":"Crossref","is-referenced-by-count":153,"title":["Clonidine and Gilles de la Tourette's syndrome: Double\u2010blind study using objective rating methods"],"prefix":"10.1002","volume":"21","author":[{"given":"Christopher G.","family":"Goetz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Carroll","family":"Susan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Como","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"492","article-title":"Gilles de la Tourette syndrome: International Registry","volume":"56","author":"Abuzzahab FS","year":"1973","journal-title":"Minn Med"},{"key":"e_1_2_1_3_2","volume-title":"American Psychiatric Association Committee on Nomenclature and Statistics: Diagnostic and Statistical Manual of Mental Disorders","year":"1980"},{"key":"e_1_2_1_4_2","first-page":"377","article-title":"New Pharmacological approaches in the treatment of Tourette syndrome","volume":"35","author":"Borison RL","year":"1982","journal-title":"Adv Neurol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91614-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780250036004"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919127"},{"key":"e_1_2_1_8_2","volume-title":"The Minnesota Multiphasic Personality Inventory Manual","author":"Hathway SR","year":"1951"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.3.343"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070109"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0035993"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1960.tb01232.x"},{"key":"e_1_2_1_13_2","first-page":"383","article-title":"Clinical efficacy of haloperidol, pimozide, penfluridol, and clonidine in the treatment of Tourette syndrome","volume":"35","author":"Shapiro AK","year":"1982","journal-title":"Adv Neurol"},{"key":"e_1_2_1_14_2","volume-title":"Gilles de la Tourette syndrome","author":"Shapiro AK","year":"1978"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100081011"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.11.1315"},{"key":"e_1_2_1_17_2","first-page":"329","article-title":"Behavior disturbance in children with Tourette syndrome","volume":"35","author":"Wilson RS","year":"1982","journal-title":"Adv Neurol"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410210313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410210313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:31:56Z","timestamp":1697851916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410210313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1002\/ana.410210313"],"URL":"https:\/\/doi.org\/10.1002\/ana.410210313","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}