{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:33:09Z","timestamp":1787592789954,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6400,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We tested the hypothesis that abnormalities of the abducting eye in internuclear ophthalmoplegia reflect an adaptive process that helps overcome the adduction weakness of the opposite eye. This response operates under the constraints of Hering's law of equal innervation: any attempt to increase the innervation to a weak muscle in one eye must be accompanied by a commensurate increase in innervation to the yoke muscle in the other eye. In 4 patients with internuclear ophthalmoplegia, we patched one eye for 1 to 5 days to allow time for the central nervous system to optimize innervation for the habitually viewing eye. We predicted that there would be a conjugate adjustment of innvervation that would diminish the abduction overshoot and backward postsaccardic drift made by the habitually viewing eye. This was the case in 3 of our 4 patients. Our findings show that the abduction nystagmus is a manifestation of a normal adaptive response in some patients with INO.<\/jats:p>","DOI":"10.1002\/ana.410210411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:40:49Z","timestamp":1104601249000},"page":"383-388","source":"Crossref","is-referenced-by-count":77,"title":["Abduction nystagmus in internuclear ophthalmoplegia"],"prefix":"10.1002","volume":"21","author":[{"given":"David S.","family":"Zee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Hain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Carl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040405"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500320004002"},{"key":"e_1_2_1_4_2","first-page":"608","article-title":"Two neuronal groups associated with the medial longitudinal fasciculus (MLF) of cat and rat that convey vestibular impulses to the cerebellar flocculus","volume":"9","author":"Blanks RHI","year":"1983","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_5_2","first-page":"307","volume-title":"Adaptive Processes in Visual and Oculomotor Systems","author":"Cannon SC","year":"1986"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460040017001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901250106"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp015998"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040010208004"},{"key":"e_1_2_1_10_2","first-page":"1506","article-title":"Internuclear ophthalmoplegia: recovery and plasticity","volume":"19","author":"Doslak MJ","year":"1980","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237082"},{"key":"e_1_2_1_12_2","unstructured":"KapoulaZ HainTC ZeeDS et al:Adaptive changes in postsaccadic drift induced by patching one eye. 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