{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:52:04Z","timestamp":1789451524089,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6339,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Creutzfeldt\u2010Jakob disease (CJD) is a rare dementia that is generally found in older people and is caused by unusual infectious pathogens or prions. Using rabbit antisera raised against hamster scrapie prion proteins (HaPrP<jats:sup>Sc<\/jats:sup>), we identified by immunoblotting human CJD prion proteins (HuPrP<jats:sup>CJD<\/jats:sup>) in the brains of 14 patients dying of CJD. Extracts from 6 of the patients were transmitted to mice after prolonged incubation. The rabbit antisera raised against HaPrP<jats:sup>Sc<\/jats:sup> also reacted with the mouse CJD prion proteins (MoPrP<jats:sup>CJD<\/jats:sup>) found in the brains of these experimentally infected mice. When mice were immunized with HuPrP<jats:sup>CJD<\/jats:sup>, they produced antibodies that reacted with HuPrP<jats:sup>CJD<\/jats:sup> but not with MoPrP<jats:sup>CJD<\/jats:sup>. Mice immunized with MoPrP<jats:sup>CJD<\/jats:sup> produced antibodies to neither murine nor human prion proteins. Our results provide evidence for host species\u2010\u2010specific epitopes on prion proteins. The existence of such epitopes is consistent with the apparent lack of an immune response during prion infections and the finding that prion protein molecules are encoded by host genes.<\/jats:p>","DOI":"10.1002\/ana.410210611","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:42:30Z","timestamp":1104601350000},"page":"589-595","source":"Crossref","is-referenced-by-count":64,"title":["Immunoblotting of Creutzfeldt\u2010Jakob disease prion proteins: Host species\u2014specific epitopes"],"prefix":"10.1002","volume":"21","author":[{"given":"Jeffrey M.","family":"Bockman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley B.","family":"Prusiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Kingsbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.5.848"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.3.518"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90662-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/310418a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.4.997"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120202"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-11-2471"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_10_2","series-title":"Foundation for the Study of the Nervous System","first-page":"107","volume-title":"Molecular Mechanisms of Pathogenesis of Central Nervous System Disorders","author":"Brown P","year":"1986"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602273140904"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509193131205"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.28.4.350"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90281-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/315331a0"},{"key":"e_1_2_1_16_2","first-page":"13","volume-title":"Slow Transmissible Diseases of the Nervous System","author":"Dickinson AG","year":"1979"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.142303"},{"key":"e_1_2_1_18_2","first-page":"87","volume-title":"Slow Transmissible Diseases of the Nervous System","author":"Gibbs CJ","year":"1979"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.388"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3897.1023"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.12.6268"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509193131207"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.9.945"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-39-3-487"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.3.1176-1180.1981"},{"key":"e_1_2_1_26_2","volume-title":"Jakob\u2010Creutzfeldt disease","author":"Kirschbaum WR","year":"1968"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200205"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1986.5.315"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.17.6372"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.1.223"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4263"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.3.559"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050212"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2310"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90333-2"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403083101021"},{"key":"e_1_2_1_39_2","first-page":"33","article-title":"Scrapie and Creutzfeldt\u2010Jakob disease prions","volume":"2","author":"Prusiner SB","year":"1985","journal-title":"Microbiol Sci"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00269a050"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00562a028"},{"key":"e_1_2_1_42_2","first-page":"181","article-title":"Prions\u2014infections pathogens causing the spongiform encephalopathies","volume":"1","author":"Prusiner SB","year":"1985","journal-title":"CRC Crit Rev Clin Neurobiol"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90168-X"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611063151919"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.3.712"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.1.1"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7358"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689997"},{"key":"e_1_2_1_49_2","first-page":"195","volume-title":"Progress in Neuropathology","author":"Tateishi J","year":"1983"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.5.2035"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410210611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410210611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:02:53Z","timestamp":1697896973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410210611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1002\/ana.410210611"],"URL":"https:\/\/doi.org\/10.1002\/ana.410210611","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}