{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:37:19Z","timestamp":1790836639323,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperosmotic blood\u2014brain barrier disruption transiently increases the rate of blood\u2010to\u2010tissue transport of water soluble compounds to normal brain and has been used in brain tumor patients to increase the delivery of chemotherapeutic drugs. This method remains controversial; debate concerns the extent to which it increases drug delivery to brain tumors. Ethylnitrosourea (ENU)\u2010induced gliomas in rats have the lowest rate of blood\u2010to\u2010tissue transfer of the water\u2010soluble compound alpha\u2010aminoisobutyric acid of all experimental brain tumor studied to date. To gain further understanding about the effect of hyperosomotic blood\u2014brain barrier disruption in brain tumors, we measured the unidirectional blood\u2010to\u2010tissue transfer constant of alpha\u2010aminoisobutyric acid in ENU\u2010induced brain tumors in rats after hyperosmotic disruption. Hyperosmotic blood\u2014brain barrier disruption with 1.6 osmolar mannitol resulted in an averaged whole\u2010tumor transfer constant of 0.013 \u00b1 0.003 (standard error) mL\/(g\/min), compared to a transfer constant of 0.007 \u00b1 0.002 mL\/(g\/min) for ENU\u2010induced gliomas in the contralateral undisrupted hemisphere, a difference that was not significant. In contrast, hyperosmotic blood\u2014brain barrier disruption produced a large and significant increase in the transfer constant of alpha\u2010aminoisobutyric acid in tumor\u2010free cortex (from 0.002 \u00b1 0.001 to 0.05 \u00b1 0.011 mL\/{g\/min}) and in tumor\u2010free corpus callosum (from 0.001 \u00b1 0.003 to 0.017 \u00b1 0.005 mL\/{g\/min}). Hyperosmotic blood\u2014brain barrier disruption does not appear to be an efficient method with which to increase the rate of delivery of water\u2010soluble drugs to brain tumors but does result in a significant increase in the delivery rate of these drugs to normal brain tissue.<\/jats:p>","DOI":"10.1002\/ana.410220304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:49:54Z","timestamp":1104601794000},"page":"300-305","source":"Crossref","is-referenced-by-count":48,"title":["The effect of hyperosmotic blood\u2014brain barrier disruption on blood\u2010to\u2010tissue transport in ENU\u2010induced gliomas"],"prefix":"10.1002","volume":"22","author":[{"given":"Peter C.","family":"Warnke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Blasberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis 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