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The neuronal microtubule\u2010associated protein, tau, has recently been identified as an antigenic component of neurofibrillary tangels and senile plaque neurites in Alzheimer's disease. Three different polyclonal antibodies with strong tau immunoreactivity are examined in this study. These antibodies were found to immunostain tangles in normal aged brain and in brains affected by a range of neurodegenerative disorders, including Down's syndrome, Alzheimer's disease plus Parkinson's disease, progressive supranuclear palsy, and the parkinsonism\u2010dementia complex of Guam, as well as Pick bodies in Pick's disease. The findings further illustrate the relative nonspecificity of neurofibrillary lesions in neurodegenerative disorders.<\/jats:p>","DOI":"10.1002\/ana.410220411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:50:41Z","timestamp":1104601841000},"page":"514-520","source":"Crossref","is-referenced-by-count":100,"title":["Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders"],"prefix":"10.1002","volume":"22","author":[{"given":"Catharine L.","family":"Joachim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Kosik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Selkoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5613"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.4.1371"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70644-8_13"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90220-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90214-5"},{"issue":"24","key":"e_1_2_1_7_2","first-page":"12670","article-title":"Conservation of microtubule associated proteins","volume":"254","author":"Cleveland DW","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.6.2437"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.76.3.781"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049588"},{"key":"e_1_2_1_11_2","first-page":"292","article-title":"Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. 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