{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:39:05Z","timestamp":1790462345305,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6217,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported that the monoclonal antibody Alz\u201050 recognizes a protein (A68) with an apparent molecular weight of 68,000 daltons in the brains of patients who died with Alzheimer's disease, but not in brain tissue from individuals free of neurological disease. We now report that substantial quantities of this protein are found in brain tissue only from patients with Alzheimer's disease, Although trace amounts of A68 may be detected in cases of Guam\u2014Parkinson dementia complex and Pick's disease, accumulation of A68 in neuronal perikarya and particularly in neuronal processes appears to be a unique feature of Alzheimer's disease. A68 can readily be detected in cerebrospinal fluid after concentration and partial purification. These data, combined with the quantitation of immunoreactivity in other neurological diseases, suggest the usefulness of detection of A68 in cerebrospinal fluid for diagnosis of Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ana.410220412","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:50:41Z","timestamp":1104601841000},"page":"521-526","source":"Crossref","is-referenced-by-count":145,"title":["Alzheimer\u2010related neuronal protein A68: Specificity and distribution"],"prefix":"10.1002","volume":"22","author":[{"given":"Benjamin","family":"Wolozin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1159\/000152266","article-title":"A population study of senile and arteriosclerotic psychoses","volume":"19","author":"Akesson HO","year":"1969","journal-title":"Hum Hered"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/279372a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.2.307"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121107"},{"key":"e_1_2_1_7_2","first-page":"817","volume-title":"Greenfield's neuropathology","author":"Corsellis JAN","year":"1976"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule\u2010associated protein tau, a component of Alzheimer paired helical filaments","volume":"261","author":"Grundke\u2010Iqbal I","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4044"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4040"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.3.459"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90336-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91936-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90073-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/288279a0"},{"key":"e_1_2_1_16_2","volume-title":"Proceedings of the Second Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, Zurich, January 1981","author":"Davies P","year":"1981"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/319593a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3083509"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695605"},{"key":"e_1_2_1_20_2","first-page":"457","article-title":"The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome","volume":"73","author":"Burger PC","year":"1973","journal-title":"Am J Pathol"},{"key":"e_1_2_1_21_2","first-page":"287","article-title":"Down's syndrome and Alzheimer's dementia: defining an association","volume":"2","author":"Heston LL","year":"1984","journal-title":"Psychiatr Dev"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150624"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(85)90489-2"},{"key":"e_1_2_1_24_2","first-page":"35","article-title":"Paired helical filament antigen in CSF","volume":"1","author":"Mehta PD","year":"1986","journal-title":"Lancet"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410220412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410220412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:39:48Z","timestamp":1697917188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410220412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1002\/ana.410220412"],"URL":"https:\/\/doi.org\/10.1002\/ana.410220412","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}