{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:41:36Z","timestamp":1769380896894,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6217,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients with the syndrome of progressive aphasia without evidence of generalized dementia underwent postmortem neuropathological examinations. In both patients, characteristic changes of Alzheimer's disease, Pick's disease, or Creutzfeldt\u2014Jakob disease were absent. Both patients showed a focal spongiform change involving primarily layer 2 of the left inferior frontal gyrus (and temporal cortex in Patient 1) and a mild astrocytosis in layer 2 and deeper cortical layers. This focal, spongiform cortical degeneration in patients with progressive aphasia does not appear to duplicate any known central nervous system degenerative disease.<\/jats:p>","DOI":"10.1002\/ana.410220413","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:50:41Z","timestamp":1104601841000},"page":"527-532","source":"Crossref","is-referenced-by-count":113,"title":["Progressive aphasia without dementia: Two cases with focal spongiform degeneration"],"prefix":"10.1002","volume":"22","author":[{"given":"Howard S.","family":"Kirshner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguz","family":"Tanridag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Thurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"William O.","family":"Whetsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1101","article-title":"Case Records of the Massachusetts General Hospital (case 16\u20131986)","volume":"314","author":"Caplan LR","year":"1986","journal-title":"N Engl J Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190112"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120210"},{"key":"e_1_2_1_5_2","first-page":"147","article-title":"The clinical picture in Creutzfeldt\u2010Jakob disease","volume":"85","author":"Fisher CM","year":"1960","journal-title":"Trans ANA"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00684819"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130237"},{"issue":"1","key":"e_1_2_1_8_2","first-page":"102","article-title":"Progressive aphasia \u201cwithout dementia\u201d: evidence of more widespread involvement","volume":"34","author":"Gordon B","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130625"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(85)90096-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160306"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.1.61"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050170037012"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198501000-00001"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/101.2.333"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160407"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.1.1"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140104"},{"key":"e_1_2_1_20_2","first-page":"227","article-title":"Neuropathology of the cortical lesions of the parkinsonian\u2010dementia (PD) complex of Guam","volume":"17","author":"Tan NT","year":"1981","journal-title":"Clin Exp Neurol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.3.303"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510170029008"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80203-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.11.1517"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410220413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410220413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:39:52Z","timestamp":1697917192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410220413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1002\/ana.410220413"],"URL":"https:\/\/doi.org\/10.1002\/ana.410220413","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}