{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T13:08:56Z","timestamp":1698152936131},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6186,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied two familial cases of human T\u2010lymphotropic virus type I (HTLV\u2010I)\u2014associated myelopathy from the Kii Peninsula, an area of endemic adult T\u2010cell leukemia\u2010lymphoma (ATLL) in Japan. Incidence of familial clustering of HTLV\u2010I\u2014associated myelopathy was about 20%. Type C retrovirus was isolated from cultured cerebrospinal fluid and peripheral blood lymphocytes in both cases. Modes of transmission seem to be similar to those described in ATLL, although there are no reports of both HTLV\u2010I\u2014associated myelopathy and ATLL occurring in the same family. We suggest three possibilities: (1) that the virus associated with HTLV\u2010I\u2014associated myelopathy is different from the virus causing ATLL, although they seem to be morphologically and immunologically similar; (2) that HTLV\u2010I\u2014associated myelopathy may be determined by the ATLL\u2010causing virus plus a specific genetic background; and (3) some combination of factors 1 and 2.<\/jats:p>","DOI":"10.1002\/ana.410220507","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:51:10Z","timestamp":1104601870000},"page":"601-605","source":"Crossref","is-referenced-by-count":19,"title":["Familial cases of HTLV\u2010I\u2014associated myelopathy"],"prefix":"10.1002","volume":"22","author":[{"given":"Ichiro","family":"Miyai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Saida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshisuke","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutsugu","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/jvi.52.2.356-363.1984","article-title":"Physical mapping of the paralysis\u2010inducing determinant of a wild mouse ecotrophic 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