{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:11:14Z","timestamp":1785175874752,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6125,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report detailed oculomotor studies in 3 patients with central nervous system lesions and markedly decreased time constants (&lt; 2 seconds) of the vestibuloocular reflex (VOR). In 1 patient with Chiari type I malformation, serial measurements over 3 years documented a progressive decrease in the duration of postrotatory nystagmus (100 deg\/sec steps, acceleration 140 deg\/sec<jats:sup>2<\/jats:sup>) until finally there was no sustained nystagmus. At this time, the patient had no response to caloric stimulation or to sinusoidal rotation below 0.2 Hz but normal gain (peak slow\u2010phase eye velocity\/peak chair velocity) above 0.4 Hz (phase lead increased). Gaze holding, saccades, smooth pursuit, and optokinetic nystagmus were normal, but optokinetic\u2010after\u2010nystagmus disappeared. The other 2 patients (combined brainstemcerebellar atrophy) had impaired gaze holding, abnormal smooth pursuit and optokinetic nystagmus, and absent optokinetic\u2010after\u2010nystagmus. VOR gain to step and high\u2010frequency sinusoidal stimuli was increased. The neural mechanism that normally prolongs the VOR time constant may have reduced it in our patients.<\/jats:p>","DOI":"10.1002\/ana.410230107","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:53:05Z","timestamp":1104587585000},"page":"32-37","source":"Crossref","is-referenced-by-count":9,"title":["Ultralow vestibuloocular reflex time constants"],"prefix":"10.1002","volume":"23","author":[{"given":"R. W.","family":"Baloh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Beykirch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Honrubia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(82)80061-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160209"},{"key":"e_1_2_1_4_2","first-page":"563","article-title":"On\u2010line analysis of eye movements using a digital computer","volume":"51","author":"Baloh RW","year":"1980","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_1_5_2","first-page":"81","article-title":"Brainstem commissures and control of time constants of vestibular nystagmus","volume":"93","author":"Blair SM","year":"1982","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp015998"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90098-9"},{"key":"e_1_2_1_8_2","first-page":"739","article-title":"Vestibulo\u2010ocular and optokinetic deficits in albinos with congenital nystagmus","volume":"25","author":"Demer JL","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1971.34.4.661"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238748"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236599"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236613"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.04.030181.002335"},{"key":"e_1_2_1_14_2","first-page":"1154","article-title":"Vestibulo\u2010ocular reflexes of adventitiously and congenitally blind adults","volume":"27","author":"Sherman KR","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.45.3.376"},{"issue":"1","key":"e_1_2_1_16_2","first-page":"256","article-title":"The neurologic evaluation of the neonate: quantitation of the vestibulo\u2010ocular reflex","volume":"36","author":"Weissman BM","year":"1986","journal-title":"Neurology"},{"key":"e_1_2_1_17_2","first-page":"95","volume-title":"Nystagmus and Vertigo","author":"Wolfe JW","year":"1982"},{"key":"e_1_2_1_18_2","first-page":"38","article-title":"Nystagmic responses of the rhesus monkey to rotational stimulation following unilateral labyrinthectomy: final report","volume":"84","author":"Wolfe JW","year":"1977","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410230107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410230107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:08:22Z","timestamp":1697908102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410230107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/ana.410230107"],"URL":"https:\/\/doi.org\/10.1002\/ana.410230107","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}