{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:57:30Z","timestamp":1776589050580,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6094,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Protein concentration and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities were assayed in the cerebrospinal fluid (CSF) of 26 healthy normal subjects (20\u201386 years old), 27 patients with dementia of the Alzheimer type (DAT), and 10 patients with dementia of the Alzheimer type with extrapyramidal signs (EDAT). In normal subjects, there was an age\u2010related increase in CSF protein and AChE activity and a significant correlation (<jats:italic>p<\/jats:italic> &lt; 0.001) between CSF protein and BChE activity. In the DAT and EDAT groups, CSF AChE activities (mean \u00b1 SD = 17.5 \u00b1 3.6 and 15.3 \u00b1 4.4 nmol\/min\/ml, respectively) were significantly lower (<jats:italic>p<\/jats:italic> &lt; 0.05) than in 13 age\u2010matched control subjects (21.5 \u00b1 5.6 nmol\/min\/ml). In contrast, neither CSF protein concentration, BChE activity, nor the ratio of AChE\/BChE differed significantly between groups. In patients with DAT, CSF AChE activity was significantly lower (<jats:italic>p<\/jats:italic> &lt; 0.05) in subjects with an early onset compared to those with a late onset (16.4 \u00b1 3.4 and 19.7 \u00b1 2.8 nmol\/min\/ml, respectively), and activity in the latter group did not differ significantly from control values. CSF AChE activity was not related to dementia severity and did not change significantly over an 18\u2010month period. Although these results confirm a cholinergic deficit in patients with DAT, the considerable overlap of CSF AChE activity between groups and the nonsignificant correlation between AChE activity and dementia severity limit the usefulness of CSF AChE as a diagnostic marker of this disorder.<\/jats:p>","DOI":"10.1002\/ana.410230209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:55:22Z","timestamp":1104602122000},"page":"161-167","source":"Crossref","is-referenced-by-count":55,"title":["Cerebrospinal fluid cholinesterases in aging and in dementia of the alzheimer type"],"prefix":"10.1002","volume":"23","author":[{"given":"John R.","family":"Atack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur D.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley I.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(86)90164-8"},{"key":"e_1_2_1_3_2","first-page":"217","article-title":"Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type","volume":"217","author":"Soininen H","year":"1981","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90409-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90116-8"},{"key":"e_1_2_1_6_2","first-page":"46","article-title":"Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type","volume":"46","author":"Tune L","journal-title":"Ann Neurol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(86)90033-8"},{"key":"e_1_2_1_8_2","first-page":"213","article-title":"Acetylcholinesterase activity in cerebrospinal fluid of patients with Alzheimer's disease and senile dementia","volume":"213","author":"Nakano S","journal-title":"J Neurol Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90216-6"},{"key":"e_1_2_1_10_2","first-page":"319","article-title":"Neurotransmitter\u2010related enzymes in senile dementia of the Alzheimer type","volume":"319","author":"Davies P","journal-title":"Brain Res"},{"key":"e_1_2_1_11_2","first-page":"2073","article-title":"Reduced lumbar CSF somatostatin levels in Alzheimer's disease","volume":"2073","author":"Wood PL","journal-title":"Life Sci"},{"key":"e_1_2_1_12_2","first-page":"1363","article-title":"Acetylcholinesterase activity in CSF in schizophrenia, depression, Alzheimer's disease and normals","volume":"1363","author":"Deutsch SI","year":"1983","journal-title":"Biol Psychiatry"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(84)90002-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(85)90095-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.5.538"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/oxfordjournals.bmb.a072100","article-title":"The cholinergic hypothesis\u2014ten years on","volume":"63","author":"Perry EK","year":"1986","journal-title":"Br Med Bull"},{"key":"e_1_2_1_17_2","volume-title":"The Biology of Cholinesterases. 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