{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:35:51Z","timestamp":1793144151508,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6094,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The trigeminal ganglion was activated, in humans by thermocoagulation as part of the treatment of trigeminal neuralgia and in cats by electrical stimulation, and blood samples were taken from the external jugular vein for estimates of plasma levels of substance P and calcitonin gene\u2010related peptide (CGRP). In those patients who were noted at the time of coagulation to have flushed there were marked elevations of the local (cranial) levels of both peptides. However, in the nonflushing patients no changes in the peptide levels were observed. Parallel experiments in the cat revealed that the levels of substance P\u2014like and CGRP\u2010like immunoreactivity were increased during electrical stimulation of the trigeminal ganglion. The observation of elevation of substance P\u2014like and CGRP\u2010like immunoreactivity after activation of the nociceptive afferent system of the head provides new insights into a putative role of peptides in the pathophysiology of migraine and cluster headache, and suggests new areas of possible therapeutic intervention.<\/jats:p>","DOI":"10.1002\/ana.410230214","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:55:22Z","timestamp":1104584122000},"page":"193-196","source":"Crossref","is-referenced-by-count":745,"title":["Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system"],"prefix":"10.1002","volume":"23","author":[{"given":"P. J.","family":"Goadsby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Edvinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"378","article-title":"Radioimmunoassay measurement of substance P release following a meat meal","volume":"89","author":"Akande B","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.7.611"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130108"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1984.0403149.x"},{"key":"e_1_2_1_6_2","first-page":"R270","article-title":"The effect of stimulation of the trigeminal ganglion on regional cerebral blood flow in the cat","volume":"253","author":"Goadsby PJ","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(86)90060-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(84)90053-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90690-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90535-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.42.6.0696"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-5-2313"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200409"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3697.879"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511073131916"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609113151102"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.2.0307"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1983.hed2306258.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160202"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.2.517"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609113151109"},{"key":"e_1_2_1_22_2","first-page":"109","article-title":"Experimental study on the vasodilator innervation of the face","volume":"2","author":"Oka M","year":"1950","journal-title":"Med J Osaka Univ"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.42.2.0132"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/62.4.364"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.5.642"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90048-4"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00498522"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.2.0143"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90296-4"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530629"},{"key":"e_1_2_1_31_2","volume-title":"Headache and Other Head Pain","author":"Wolff HG","year":"1963"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410230214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410230214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T22:53:03Z","timestamp":1697842383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410230214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["10.1002\/ana.410230214"],"URL":"https:\/\/doi.org\/10.1002\/ana.410230214","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}