{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:22:45Z","timestamp":1779178965045,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":6065,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The brain of a 17\u2010month\u2010old boy with infantile Gaucher's disease and oculomotor apraxia was studied by light and electron microscopy. Light microscopic examination showed large perivascular accumulations of Gaucher's cells in frontal lobe white matter, severe neuronal loss in the calcarine cortex and dentate nucleus of the cerebellum, and neuronophagia and microglial nodules in the brainstem. Electron microscopy demonstrated intraneuronal cytoplasmic inclusions containing twisted tubules characteristic of Gaucher's disease in both the oculomotor nucleus and a random sample of cortex.<\/jats:p>","DOI":"10.1002\/ana.410230315","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:55:26Z","timestamp":1104602126000},"page":"300-303","source":"Crossref","is-referenced-by-count":26,"title":["Infantile gaucher's disease: A case with neuronal storage"],"prefix":"10.1002","volume":"23","author":[{"given":"Marjorie","family":"Grafe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrett","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510210020005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692212"},{"key":"e_1_2_1_4_2","first-page":"1523","article-title":"Clinical and biochemical aspects of chronic Gaucher's disease","volume":"10","author":"Matoth Y","year":"1974","journal-title":"Israel J Med Sci"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690463"},{"key":"e_1_2_1_6_2","first-page":"513","article-title":"Fine structure of central nervous system in early infantile Gaucher's disease","volume":"83","author":"Adachi M","year":"1967","journal-title":"Arch Pathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548655"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.8.994"},{"key":"e_1_2_1_9_2","first-page":"842","volume-title":"The metabolic basis of inherited disease","author":"Brady RO","year":"1983"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200208"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700720116"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091508"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/ajcp\/83.4.516","article-title":"Gaucher's disease: a case history with extensive lipid storage in the brain","volume":"83","author":"Leech RW","year":"1985","journal-title":"Am J Clin Path"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.484"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0022-2275(20)36768-7","article-title":"Isolation and characterization of glucosylsphingosine from Gaucher's spleen","volume":"15","author":"Raghaven SS","year":"1974","journal-title":"J Lipid Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb07950.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3101176"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410230315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410230315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T08:32:32Z","timestamp":1697877152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410230315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,3]]}},"alternative-id":["10.1002\/ana.410230315"],"URL":"https:\/\/doi.org\/10.1002\/ana.410230315","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}