{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:38:47Z","timestamp":1761154727768},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5912,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus type I (HTLV\u20101)\u2010associated myelopathy (HAM) has been shown to be closely related to HTLV\u2010I infection. However, the mechanism by which this disease occurs after infection with HTLV\u2010I is still obscure. We found that HAM patients have unusually high proportions of CD4<jats:sup>+<\/jats:sup>HLADR<jats:sup>+<\/jats:sup> cells, CD8<jats:sup>+<\/jats:sup>HLA\u2010DR<jats:sup>+<\/jats:sup> cells, OKT9<jats:sup>+<\/jats:sup> cells, and CD38(0KTlO)<jats:sup>+<\/jats:sup> cells in their peripheral blood, all of which suggest the presence of activated T\u2010lymphocytes. Antibody titer against HTLV\u2010I was much higher in HAM patients than in HTLV\u2010I carriers without evident neurological disease (p &lt; 0.01). Polyclonal gammopathy was also observed in most HAM patients, and 6 of 10 patients were positive for rheumatoid factor. These observations, coupled with the previous observation that corticosteroid therapy improves clinical symptoms in some patients, make it likely that continuous activation of the immune system, initiated by HTLV\u2010I infection, plays a key role in the pathogenesis of HAM.<\/jats:p>","DOI":"10.1002\/ana.410240220","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:02:49Z","timestamp":1104588169000},"page":"280-282","source":"Crossref","is-referenced-by-count":34,"title":["Activated t\u2010lymphocytes with polyclonal gammopathy in patients with human t\u2010lymphotropic virus type i\u2014associated myelopathy"],"prefix":"10.1002","volume":"24","author":[{"given":"Masataka","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaro","family":"Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shiku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230119"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91984-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210204"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.3.1508"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.6.3762"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410240220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410240220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:56:29Z","timestamp":1697864189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410240220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1002\/ana.410240220"],"URL":"https:\/\/doi.org\/10.1002\/ana.410240220","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}