{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:58:32Z","timestamp":1698364712940},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5851,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated paraffin\u2010embedded brain sections from 41 patients with Creutzfeldt\u2010Jakob disease (CJD) and from 9 with Gerstmann\u2010Str\u00e4ussler syndrome (GSS) using anti\u2014human prion protein (PrP) antisera (anti\u2014GSS kuru plaque cores and anti\u2014PrP synthetic peptide) and anti\u2014\u03b2 protein antiserum. The anti\u2014human PrP antiserum reacted with the plaques in CJD and GSS, with or without degenerative neurites (neuritic components). In addition, the anti\u2014\u03b2 protein antiserum immunolabeled kuru plaque\u2014like compact plaques in some cases of CJD. Therefore, previous morphological classifications of the plaques may not always be valid. Senile plaques labeled with anti\u2014\u03b2 protein antiserum were evident in 65% of the CJD brains and 50% of GSS brains from patients in their 60s, and in 73% of brains from CJD patients in their 70s, but not in brains from patients under 60 years of age. The incidence of the senile plaques was compatible with the normal aging process and was apparently not accelerated by the disease process of CJD or GSS. These immunostaining approaches using anti\u2014human PrP and anti\u2014\u03b2 protein antisera allow classification of plaque types and increase the reliability of the pathological diagnosis in persons with dementia.<\/jats:p>","DOI":"10.1002\/ana.410240410","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:03:39Z","timestamp":1104588219000},"page":"537-542","source":"Crossref","is-referenced-by-count":13,"title":["Immunohistochemical verification of senile and kuru plaques in Creutzfeldt\u2010Jakob disease and the allied disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Tetsuyuki","family":"Kitamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"Progress in neuropathology","author":"Wisniewski HM","year":"1973"},{"key":"e_1_2_1_3_2","first-page":"799","article-title":"Zigas V","volume":"8","author":"Klatzo I","year":"1959","journal-title":"Pathology of kuru. Lab Invest"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.3.559"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687490"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140208"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687812"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90602-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90168-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(84)80190-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90333-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200205"},{"key":"e_1_2_1_14_2","first-page":"230","article-title":"Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids","volume":"57","author":"Kitamoto T","year":"1987","journal-title":"Lab Invest"},{"key":"e_1_2_1_15_2","first-page":"435","article-title":"Immunohistochemical confirmation of Creatzfeldt\u2010Jakob disease with a long clinical course with amyloid plaque core antibodies","volume":"131","author":"Kitamoto T","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050616"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690454"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689997"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695613"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1986.5.315"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107795"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/315331a0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.355"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1987.tb00176.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(68)90154-8"},{"key":"e_1_2_1_26_2","unstructured":"OgomoriK KitamotoT TateishiJ et al. Aging and cerebral amyloid: early detection of amyloid in the human brain using biochemical extraction and immunostain.J Gerontol(in press)"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.2.269"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687003"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1987.tb03598.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198405000-00094"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410240410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410240410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T20:10:27Z","timestamp":1697919027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410240410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/ana.410240410"],"URL":"https:\/\/doi.org\/10.1002\/ana.410240410","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}