{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:01:20Z","timestamp":1757700080771},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5759,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the pathological and immunohistochemical changes in the first\u2010order neurons in the trigeminal ganglia in Creutzfeldt\u2010Jakob disease (CJD). Degenerative changes consisted of cytoplasmic vacuolation and fenestration, abundant satellite cells, neurofilament accumulation in neurons, and axonal dystrophy with spheroid formation and torpedolike structures arising from the neuronal cytoplasm. Dystrophic axons, axonal spheroids, and some ganglion cells were labeled with monoclonal antibodies to a phosphorylated epitope of neurofilaments (200 kDa). Polyclonal antibodies to purified scrapie\u2010associated fibril\/prion protein (molecular weight 27\u201330 kDa) extracted from scrapie\u2010infected hamster brains, as well as polyclonal and monoclonal antibodies to a synthetic 15\u2013amino acid polypeptide of the 27\u2010 to 30\u2010kDa protein, demonstrated variable immunoreactivity with degenerating neurons in the CJD cases, but not in the controls. Furthermore, some of the satellite cells and dystrophic axons were stained by the antibodies to the synthetic peptide. These data indicate that the first\u2010order neurons of the trigeminal ganglia may form a route by which the CJD agent may travel from the brain to the periphery or vice versa. As in other chronic neurodegenerative diseases, disturbances of neuroaxonal transport seem to occur in CJD.<\/jats:p>","DOI":"10.1002\/ana.410250119","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:08:03Z","timestamp":1104588483000},"page":"102-106","source":"Crossref","is-referenced-by-count":33,"title":["Neuronal degeneration and neurofilament accumulation in the trigeminal ganglia in creutzfeldt\u2010jakob disease"],"prefix":"10.1002","volume":"25","author":[{"given":"Don C.","family":"Guiroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susarla K.","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Clarence J.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Messenheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarala","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Carleton","family":"Gajdusek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)34170-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/98.4.595"},{"key":"e_1_2_1_4_2","first-page":"553","volume-title":"Add Int Arch Allergy","author":"Beck E","year":"1969"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.3.441"},{"key":"e_1_2_1_6_2","first-page":"188","article-title":"\u00fcber den Bau der Spinalganglien unter nor\u2010malen u pathologischen Verh\u00e4ltnissen","volume":"11","author":"Bielschowsky M","year":"1908","journal-title":"J Psychol Neurol"},{"key":"e_1_2_1_7_2","first-page":"107","article-title":"Immunological study of patients with Creutzfeldt\u2010Jakob disease and other chronicneurological disorders: Western blots recognition of infection\u2010specific proteins by scrapie virus antibody","volume":"3","author":"Brown P","year":"1986","journal-title":"Dis Neurosci"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602273140904"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160305"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(83)90271-6"},{"key":"e_1_2_1_11_2","first-page":"319","article-title":"Ocular effects of scrapie agent in hamsters: preliminary observations","volume":"16","author":"Buyukmihci N","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1169"},{"key":"e_1_2_1_13_2","first-page":"177","article-title":"Die Struktur der sensiblen Ganglien des Menschen und der Tiere","volume":"16","author":"Cajal y Ramon S","year":"1906","journal-title":"Ergeb Anat Entwicklungs"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90421-4"},{"key":"e_1_2_1_15_2","first-page":"93","volume-title":"Cytology and Cellular Pathology of the Nervous System","author":"de Castro F","year":"1932"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.10.1483"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90671-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403212901220"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/295149a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91091-1"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121110"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197706092962308"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.803711"},{"key":"e_1_2_1_24_2","first-page":"90","volume-title":"Immunocyto\u2010chemistry","author":"Sternberger L","year":"1986"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410250119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410250119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410250119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T08:53:48Z","timestamp":1697964828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410250119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/ana.410250119"],"URL":"https:\/\/doi.org\/10.1002\/ana.410250119","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}