{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T19:59:38Z","timestamp":1726171178739},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous comparisons between presenile Alzheimer's disease (AD) and senile dementia of the Alzheimer type (SDAT) did not control for disease severity and duration. In the current study, 18 patients with each diagnosis were matched for disease duration, cognitive dysfunction, and behavioral symptoms (using the modified Mini\u2010Mental Status [mMMS] examination and the Blessed Dementia Rating Scale [BDRS]). Regional cerebral blood flow (rCBF) was quantified by the <jats:sup>133<\/jats:sup>xenon inhalation technique, and several indices of tissue perfusion were examined. The two variables of primary interest were relative gray\u2010matter weight and a gray\u2010matter perfusion index, the initial slope index. Presenile onset was associated with loss of gray\u2010matter relative weight (35% in presenile patients versus 39% in senile patients and healthy control subjects, <jats:italic>p<\/jats:italic> = 0.006), with neither perfusion nor disease severity differences between the two dementia samples. This loss of gray matter was significantly related to both severity and duration of disease in the patients with presenile AD, but not in patients with SDAT. These findings lend support to previous suggestions of greater degenerative process in presenile AD and confirm the need to examine and control age of onset in future investigations of AD. Further, correlation analysis suggests greater proportion of common variance among clinical and physiological indices in presenile AD.<\/jats:p>","DOI":"10.1002\/ana.410250203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:08:29Z","timestamp":1104588509000},"page":"117-124","source":"Crossref","is-referenced-by-count":23,"title":["Gray\u2010matter degeneration in presenile alzheimer's disease"],"prefix":"10.1002","volume":"25","author":[{"given":"Isak","family":"Prohovnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenn","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold A.","family":"Sackeim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"35","volume-title":"Alzheimer's disease, senile dementia and related disorders","author":"Grufferman S","year":"1978"},{"key":"e_1_2_1_3_2","first-page":"71","volume-title":"Alzheimer's disease, senile dementia and related disorders","author":"Roth M","year":"1978"},{"key":"e_1_2_1_4_2","first-page":"71","volume-title":"Clinical aspects of Alzheimer's disease and senile dementia","author":"Wang HS"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(85)90139-8"},{"key":"e_1_2_1_6_2","first-page":"579","volume-title":"Alzheimer's disease, senile dementia and related disorders","author":"Katzman R"},{"key":"e_1_2_1_7_2","first-page":"219","volume-title":"Handbook of regional cerebral blood flow","author":"Risberg J","year":"1987"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.6.931"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.6.645"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.11.962"},{"key":"e_1_2_1_13_2","first-page":"51","volume-title":"Handbook of rCBF","author":"Prohovnik I","year":"1987"},{"key":"e_1_2_1_14_2","first-page":"87","volume-title":"Functional radionuclide imaging of the brain","author":"Prohovnik I","year":"1983"},{"issue":"1","key":"e_1_2_1_15_2","first-page":"551","article-title":"Vascular compartment in noninvasive 133Xe clearance","volume":"7","author":"Prohovnik I","year":"1987","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1986.11739761"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.6.3.245"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70054-5_7"},{"key":"e_1_2_1_19_2","first-page":"119","volume-title":"Cerebral circulation","author":"Obrist WD","year":"1980"},{"key":"e_1_2_1_20_2","first-page":"15","volume-title":"Alzheimer's disease, senile dementia and related disorders","author":"Constantinidis J"},{"key":"e_1_2_1_21_2","first-page":"149","article-title":"Neuronal loss in the basal forebrain cholinergic system is more marked in Alzheimer's disease than in senile dementia of the Alzheimer type","volume":"14","author":"Whitehouse PJ","year":"1983","journal-title":"Ann Neurol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140306"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.1.123"},{"key":"e_1_2_1_24_2","first-page":"236","volume-title":"Neuropsychology of memory","author":"Albert M","year":"1984"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.507"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6422.961"},{"key":"e_1_2_1_27_2","first-page":"706","article-title":"CT assessment of CSF spaces in the brain in demented and nondemented patients over 60 years of age","volume":"4","author":"Kohlmeyer K","year":"1983","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050230040015"},{"key":"e_1_2_1_29_2","first-page":"945","article-title":"Positron emission tomography in brain aging and dementia: the effect of focal atrophy on regional metabolic calculations","volume":"27","author":"Chawluk J","year":"1986","journal-title":"J Nucl Med"},{"key":"e_1_2_1_30_2","first-page":"454","article-title":"The influence of regional cortical atrophy on regional cortical metabolism in aging and dementia of the Alzheimer type","volume":"12","author":"Moroi S","year":"1986","journal-title":"Soc Neurosci Abst"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.3.431"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.4.315"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100209"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.6.0773"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85860-4_3"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190306"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.16.5.515"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(85)90139-X"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.56"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.3.229"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220208"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410250203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410250203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T03:19:07Z","timestamp":1697944747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410250203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1002\/ana.410250203"],"URL":"https:\/\/doi.org\/10.1002\/ana.410250203","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}