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The electrogenic sodium\/potassium pump, which digitalis specifically inhibits, is responsible for part of the resting membrane potential and also the activity\u2010related membrane hyperpolarization following high\u2010frequency impulses. The latter causes intermittent conduction block in demyelinated fibers. Therefore, digitalis might be expected to reverse demyelinative conduction blocks by reducing the threshold at the blocking node. Somatosensory evoked potentials were monitored in 11 rats with spinal cord demyelination before and after systemic administration of ouabain (0.1\u20130.6 mg or 0.21\u20131.58 mg\/kg IP). In all rats, slowed conduction velocity of the compound action potential through the lesion was significantly reversed, and failure to transmit high\u2010frequency impulses was improved upon. The amplitude of the cortical somatosensory evoked potentials also increased significantly. Digitalis is a promising therapeutic agent for trial in patients with multiple sclerosis.<\/jats:p>","DOI":"10.1002\/ana.410250209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:08:29Z","timestamp":1104588509000},"page":"159-165","source":"Crossref","is-referenced-by-count":27,"title":["Effect of digitalis on central demyelinative conduction block in vivo"],"prefix":"10.1002","volume":"25","author":[{"given":"Ryuji","family":"Kaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin J.","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Lectures on diseases of the nervous system","author":"Charcot JM","year":"1877"},{"key":"e_1_2_1_3_2","first-page":"357","volume-title":"Demyelinating disease: basic and clinical 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