{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:58:15Z","timestamp":1762160295633},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5700,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The resemblance of the filamentous inclusions in inclusion body myositis (IBM) to mumps virus nucleoproteins and the report of immunoreactivity of the inclusions for mumps virus antigens have implicated the mumps virus in the etiology of IBM. We tested the mumps virus hypothesis by in\u2010situ hybridization with a cDNA probe specific for the mumps virus nucleocapsid gene, and immunocytochemically with antibodies against \u201csoluble\u201d and \u201cviral\u201d mumps antigens. The tests were performed on muscle specimens (IBM, 20; acid maltase deficiency, 4; chloroquine myopathy, 2; nonweak control subjects, 5) and mumps virus\u2013infected and uninfected HEp\u20102 cells. The in\u2010situ hybridization study showed a strong specific signal in the infected HEp\u20102 cells but no specific signal in IBM, other myopathies, or nonweak control subjects. The immunocytochemical study showed specific binding of the antimumps antibodies to the infected HEp\u20102 cells but demonstrated only nonspecific binding of these antibodies around rimmed vacuoles in IBM, acid maltase deficiency, and chloroquine myopathy. These studies cast doubt on the mumps hypothesis of IBM.<\/jats:p>","DOI":"10.1002\/ana.410250309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:08:35Z","timestamp":1104588515000},"page":"260-264","source":"Crossref","is-referenced-by-count":50,"title":["Inclusion body myositis: The mumps virus hypothesis"],"prefix":"10.1002","volume":"25","author":[{"given":"Hiroshi","family":"Nishino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burt K.","family":"Rima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.158.3807.1453"},{"key":"e_1_2_1_3_2","first-page":"649","article-title":"Myxovirus\u2010like structures and accompanying nuclear changes in chronic polymyositis","volume":"86","author":"Chou SM","year":"1968","journal-title":"Arch Pathol"},{"key":"e_1_2_1_4_2","first-page":"240","article-title":"Inclusion body myositis","volume":"25","author":"Yunis EJ","year":"1971","journal-title":"Lab Invest"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.1.8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"e_1_2_1_7_2","first-page":"1423","volume-title":"Myology","author":"Mikol J","year":"1986"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80197-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692226"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050913"},{"issue":"1","key":"e_1_2_1_11_2","first-page":"204","article-title":"Mumps virus antigen in inclusion body myositis (IBM)","volume":"35","author":"Chou SM","year":"1985","journal-title":"Neurology"},{"key":"e_1_2_1_12_2","first-page":"36","article-title":"Mumps antigen in inclusion\u2010body myositis","volume":"9","author":"Chou SM","year":"1986","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-5-977"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90808-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(87)90031-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-4754.1982.tb01001.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-01082-7.50026-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90249-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/144.2.154"},{"key":"e_1_2_1_20_2","first-page":"3","volume-title":"In situ hybridization. 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