{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:41:35Z","timestamp":1789940495453,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5516,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To estimate the replication of the human T\u2010cell leukemia virus type I (HTLV\u2010I) in patients with HTLV\u2010I\u2010associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV\u2010I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV\u2010I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymtopmatic carriers. Therefore, HAM\/TSP development is associated with a high level of HTLV\u2010I replication. In addition, lymphocytes from 3 patients with HAM\/TSP showed monoclonal integration of HTLV\u2010I DNA, indicating adult T\u2010cell leukemia.<\/jats:p>","DOI":"10.1002\/ana.410260304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:14:36Z","timestamp":1104588876000},"page":"331-335","source":"Crossref","is-referenced-by-count":122,"title":["Increased replication of HTLV\u2010I in HTLV\u2010I\u2013associated 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