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Specificity of antibodies was assessed by homologous competitive inhibition on Western blot assay. Six patients (3 with chronic progressive myelopathy, 1 with chronic inflammatory polyradiculoneropathy, 1 with motor neuron disease, and 1 with tension headache) had high\u2010titer HTLV\u2010I antibodies. Twelve patients (5 with multiple sclerosis, 1 with chronic progressive myelopathy, 2 with chronic inflammatory polyradiculoneuropathy, 2 with myasthenia gravis, and 2 with motor neuron disease) had low\u2010titer HTLV\u2010I antibodies that reached with a single gag protein, p19, or p24, on Western blot assay. In 4 (2 with multiple sclerosis, 1 with chronic progressive myelopathy, and 1 with chronic inflammatory polyradiculoneuropathy) of these 12, the antibodies that were all directed to p19 were determined to be specific by homologous competitive inhibition. In the remaining 8 patients (3 with multiple sclerosis, 1 with chronic inflammatory polyradiculoneuropathy, 2 with myasthenia gravis, 2 with motor neuron disease), restricted reactions against p19 or p24 were considered to be nonspecific because they were not inhibited by homologous competitive inhibition. The results suggest that in some patients chronic myeloneuropathy diagnosed as chronic progressive multiple sclerosis, chronic progressive myelopathy, and chronic inflammatory polyradiculoneuropathy may be associated with HTLV\u2010I or related retroviruses.<\/jats:p>","DOI":"10.1002\/ana.410260404","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:15:15Z","timestamp":1104588915000},"page":"515-522","source":"Crossref","is-referenced-by-count":10,"title":["Low\u2010titer antibodies reactive with HTLV\u2010I gag P19 in patients with chronic 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