{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T08:05:34Z","timestamp":1767513934530},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine whether neurological and neuropsychological abnormalities are associated with clinical manifestations of human immunodeficiency virus type 1 (HIV\u20101) infection in men who do not have acquired immunodeficiency syndrome (AIDS), we performed a historical prospective and cross\u2010sectional study. One hundred HIV\u20101 seropositive homosexual or bisexual men, of whom 26 had AIDS\u2010related complex, 31 had generalized lymphadenopathy, and 43 had no signs or symptoms of HIV\u20101 infection, and 157 HIV\u20101 seronegative men were enrolled from a cohort of 6,701 men who were originally recruited between 1978 and 1980 for studies of hepatitis B virus infection. Evaluation included medical history, physical examination, and neuropsychological tests. Of 26 HIV\u20101 seropositive subjects with AIDS\u2010related complex, 11 (42%) reported neurological, cognitive, or affective symptoms compared with 30 (19%) of 157 HIV\u20101 seronegative subjects (relative risk \u2248 2.2, <jats:italic>p<\/jats:italic> = 0.02). On neuropsychological testing, subjects with AIDS\u2010related complex performed at a significantly lower level than the HIV\u20101 seronegative group (<jats:italic>p<\/jats:italic> = 0.001). A significantly higher percentage of subjects with AIDS\u2010related complex (8[31%] of 26) than HIV\u20101 seronegative subjects (19 [12%] of 157) had abnormal results on two or more neuropsychological tests (rate ratio = 2.5, <jats:italic>p<\/jats:italic> = 0.03). symptoms and impairment on neuropsychological tests were correlated only within the group who had AIDS\u2010related complex. Subjects with generalized lymphadenopathy and subjects who had no signs or symptoms of HIV\u20101 infection were not different from HIV\u20101 seronegative subjects with respect to symptoms or performance on neuropsychological tests. Absolute T\u2010helper lymphocyte count and estimated duration of HIV\u20101 infection were not associated with neuropsychological test results. These findings suggest that neurological and neuropsychological abnormalities are associated with AIDS\u2010related complex but not with asymptomatic HIV\u20101 infection.<\/jats:p>","DOI":"10.1002\/ana.410260503","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:15:53Z","timestamp":1104588953000},"page":"592-600","source":"Crossref","is-referenced-by-count":165,"title":["Neurological and neuropshychological manifestations of HIV\u20101 infection: Association with AIDS\u2010related complex but not asymptomatic HIV\u20101 infection"],"prefix":"10.1002","volume":"26","author":[{"given":"Robert S.","family":"Janssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew 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