{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:03:01Z","timestamp":1792213381265,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rate at which profound hyponatremia should be corrected is the focus of a recent clinical debate. We prospectively studied neurological outcomes with serial magnetic resonanace imaging in 13 hyponatremic subjects with serum sodium concentrations of less than 115 mmol\/L (mean initial serum sodium concentration, 103.7; range, 93\u2013113 mmol\/L). All subjects were corrected to mildly hyponatremic levels at 24 hours and ultimately underwent an increase in serum sodium concentration of 25 mmol\/L without development of hypernatremia. Magnetic resonance imaging revealed the development of pontine lesions in 3 patients. The correction rate of hyponatremia over the first 24 hours was significantly faster in patients with pontine lesions (mean \u00b1 SD, 1.25 \u00b1 0.4 mmol\/(L \u00b1 hr) versus 0.74 \u00b1 0.3 mmol\/(L \u00b1 hr); \u00b1&lt;0.05). Initial sodium concentration was also significantly lower in the pontine lesion group (97.3 \u00b1 6.7 vs 105.6 \u00b1 5.2 mmol\/L,<jats:italic>p<\/jats:italic> \u00b1 &lt;0.05). We conclude that the correction rate of hyponatremia plays a significant role in the pathogenesis of pontine lesions in individuals with profound hyponatremia who undergo large increases in sodium concentration as a result of severe initial hyponatremia.<\/jats:p>","DOI":"10.1002\/ana.410270110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:17:51Z","timestamp":1104589071000},"page":"61-66","source":"Crossref","is-referenced-by-count":157,"title":["Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: A prospective magnetic resonance imaging study"],"prefix":"10.1002","volume":"27","author":[{"given":"John E.","family":"Brunner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M.","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Haggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davida F.","family":"Kruger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanton 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