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Pain and thermal sensibility were less serverely affected. Most had evidence of autonomic insufficiency. In some this was servere, with Adie's pupils, fixed tachycardia, and orthostatic hypotension. The course ranged from an abrupt, devastating onset to indolent progression over years. Stabilization or functional improvement occurred in 6 patients, 2 of whom received no drug therapy. Sensory nerve conduction studies and examination of nerve biopsy specimens demonstrated a wide spectrum in the severity of loss of large myelinated fibers. The cutaneous nerves of 6 patients had perivascular mononuclear infiltrates without necrotizing arteritis. Examination of biopsy specimens of dorsal root ganglia in 3 patients revealed lymphocytic (T\u2010cell) infiltration in the dorsal roots and ganglia, with focal clusters around neurons. In the more mildly affected ganglia, individual sensory neurons were undergoing degeneration. In the most advanced case, very few neurons remained. The possibility of Sj\u00f6gren's syndrome should be considered in patients, especially women, who develop acute, subacute, or chronic sensory and autonomic neuropathies, with ataxia and kinesthetic loss.<\/jats:p>","DOI":"10.1002\/ana.410270313","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:19:49Z","timestamp":1104589189000},"page":"304-315","source":"Crossref","is-referenced-by-count":309,"title":["Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"27","author":[{"given":"J. W.","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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