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In rabbits and in rats with experimental autoimmune myasthenia gravis, decremental muscle response to 3 Hz repetitive nerve stimulation worsened significantly after injection of the citrate anticoagulant. The worsened neuromuscular transmission defect was reversed by the administration of calcium. When used for anticoagulation, citrate reduces serum ionized calcium levels and thus may aggravate myasthenic weakness and endanger patients during or immediately after plasmapheresis.<\/jats:p>","DOI":"10.1002\/ana.410270316","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:19:49Z","timestamp":1104589189000},"page":"328-330","source":"Crossref","is-referenced-by-count":10,"title":["Citrate\u2010Induced impairment of neuromuscular transmission in human and experimental autoimmune myasthenia gravis"],"prefix":"10.1002","volume":"27","author":[{"given":"I.","family":"Wirguin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Shinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Argov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/jama.1986.03380100107031","article-title":"The utility of therapeutic plasmapheresis for neurological disorders","volume":"256","year":"1986","journal-title":"JAMA"},{"key":"e_1_2_1_3_2","first-page":"1025","article-title":"Hazards of apheresis","volume":"2","year":"1982","journal-title":"Lancet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510180028007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1985.tb00902.x"},{"key":"e_1_2_1_6_2","first-page":"1","volume-title":"Aids to the examination of the peripheral nervous system","year":"1986"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520030045010"},{"key":"e_1_2_1_8_2","first-page":"986","article-title":"Radioimmunoassay of antibodies to acetylcholine receptor in serum of myasthenia gravis patients","volume":"14","author":"Brenner T","year":"1978","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1980.60.2.396"},{"key":"e_1_2_1_10_2","first-page":"295","volume-title":"The neuromuscular junction","author":"Swift TR","year":"1984"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00470340088008"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480170038003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.24.10.986"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26286152904.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb05920.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92596-4"},{"key":"e_1_2_1_17_2","first-page":"209","volume-title":"Plasmapheresis and the immunobiology of myasthenia gravis","author":"Lisak RP","year":"1979"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410270316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410270316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:54:11Z","timestamp":1697997251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410270316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1002\/ana.410270316"],"URL":"https:\/\/doi.org\/10.1002\/ana.410270316","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}