{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:44:57Z","timestamp":1791405897682,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cerebral cortical changes in 10 cases with Pick's disease were studied immunocytochemically and ultrastructurally. All cases contained Pick's argentophilic bodies and ballooned neurons. The antibodies against phosphorylated tau proteins that intensely stained all Pick bodies recognized numerous neuronal processes around Pick body\u2013bearing cells and focal portions in the perikarya of ballooned neurons. Monoclonal and polyclonal anti\u2010ubiquitin antibodies stained not only some Pick bodies with variable intensity, but also the perikarya of all ballooned neurons. Ultrastructurally, Pick bodies consisted of accumulation of randomly oriented, approximately 15\u2010nm straight filaments and paired twisted profiles with a minimal diameter of 13 nm, maximal diameter of 26 nm, and twist periodicity of 120 nm. These Pick body\u2013type filaments were also observed in the perikarya of ballooned neurons and neuronal processes around Pick body\u2013bearing cells. Our studies demonstrate, for the first time, the characteristic pathological feature of neuropil in Pick's disease. Pick body\u2013bearing cells and ballooned neurons show unique immunocytochemical and ultrastructural properties that may be a clue to the pathogenesis of Pick's disease.<\/jats:p>","DOI":"10.1002\/ana.410270407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:19:53Z","timestamp":1104571193000},"page":"394-405","source":"Crossref","is-referenced-by-count":103,"title":["Immunocytochemical and ultrastructural studies of Pick's 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