{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:18:12Z","timestamp":1787501892598,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5182,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We evaluated the effect of posthypoxic glucose supplement in a neonatal hypoxic\u2010ischemic animal model. Seven\u2010day\u2010old rats underwent bilateral ligation of the carotid arteries, followed by exposure to an 8% oxygen atmosphere for 1 hour. The extent of hypoxic\u2010ischemic brain damage was assessed histologically 72 hours later. Gulcose load immediately after the end of the hypoxic exposure reduced the volume of neocortical infarction to 37% of the unsupplemented value, and attenuated ischemic damage in the striatum and the dentate gyrus. At the end of the hypoxic exposure, the brain level of glucose was 0.3 mmol\/kg and the level of lactate, 9 mmol\/kg. Glucose supplement produced a rapid rise in brain glucose level to 3 to 5 mmol\/kg over the next 2 hours. Lactate in both brain and plasma gradually fell toward the baseline level during the first hour of recovery. Posthypoxic glucose supplement slightly retarded lactate restitution. At any period of this neonatal model, brain lactate levels did not exceed the toxic level, which is postulated to be responsible for cerebral infarction in adult ischemic models. These results illustrate the important role of glucose in the development of neonatal hypoxic\u2010ischemic encephalopathy and the fact that full cortical infarction can develop even if brain lactate levels are low.<\/jats:p>","DOI":"10.1002\/ana.410280203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:26:34Z","timestamp":1104571594000},"page":"122-128","source":"Crossref","is-referenced-by-count":96,"title":["Posthypoxic glucose supplement reduces hypoxic\u2010ischemic brain damage in the neonatal rat"],"prefix":"10.1002","volume":"28","author":[{"given":"Haruo","family":"Hattori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude G.","family":"Wasterlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1152\/ajplegacy.1941.135.2.387","article-title":"Mechanisms for the maintenance of life in the newborn during anoxia","volume":"135","author":"Himwich HE","year":"1942","journal-title":"Am J Physiol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197404000-00004"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb11875.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500140019003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.35"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.11.1239"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.2.222"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb05173.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.3.570"},{"issue":"1","key":"e_1_2_1_11_2","first-page":"262","article-title":"Hyperglycemia and diabetes improve outcome in a rat model of anoxia\/ischemia","volume":"34","author":"Jernigan J","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.4.519"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91283-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017638"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1523\/JNEUROSCI.04-03-00793.1984","article-title":"An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice","volume":"4","author":"Whittingham TS","year":"1984","journal-title":"J Neurosci"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.34"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00693778"},{"key":"e_1_2_1_18_2","first-page":"A110","article-title":"Accentuation of hypoxic\/anoxic brain injury by postexposure infusion of glucose solutions","volume":"32","author":"Courten\u2010Myers GM","year":"1982","journal-title":"Neurology"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.7.663"},{"key":"e_1_2_1_20_2","first-page":"279","article-title":"Increased mortality from hemispheral edema from release of MCA occlusion","volume":"18","author":"Myers R","year":"1987","journal-title":"Stroke"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.4.355"},{"issue":"1","key":"e_1_2_1_22_2","first-page":"88","article-title":"Vulnerability of the dentate in a neonatal rat model of hypoxia\u2010ischemia","volume":"37","author":"Massarweh WF","year":"1987","journal-title":"Neurology"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.5.713"},{"key":"e_1_2_1_24_2","first-page":"15","volume-title":"A stereotaxic atlas of the developing rat brain","author":"Sherwood NM","year":"1970"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198510000-00005"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50109-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91007-0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.5.577"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1982.22"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198706000-00002"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb04837.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.2.245"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3375817"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.18"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1986.108"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.8.1115"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.3.396"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240508"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/272827a0"},{"key":"e_1_2_1_41_2","first-page":"663","volume-title":"Oxygen transport to tissue","author":"Varnes ME","year":"1984"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90765-2"},{"key":"e_1_2_1_43_2","first-page":"236","volume-title":"Neurology of the newborn","author":"Volpe JJ","year":"1987"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.1.4"},{"key":"e_1_2_1_45_2","first-page":"338","article-title":"Mannitol therapy in perinatal hypoxic\u2010ischemic brain damage","volume":"24","author":"Mujsce DJ","year":"1988","journal-title":"Ann Neurol"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410280203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410280203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:42:06Z","timestamp":1698003726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410280203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,8]]}},"alternative-id":["10.1002\/ana.410280203"],"URL":"https:\/\/doi.org\/10.1002\/ana.410280203","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}