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On the basis of these findings, it is proposed that NMDA antagonists may be beneficial as adjunctive treatment in the therapy of Parkinson's disease. CPP locally injected into the subthalamic nucleus, entopeduncular nucleus\u2013the rat homologue of the internal pallidal segment\u2013or substantia nigra pars reticulata of monoamine\u2010depleted rats stimulates locomotor activity and alleviates rigidity, whereas local microinjection of CPP into the neostriatum is ineffective. These results make it unlikely that the neostriatum is the site of the antiparkinsonian action of NMDA antagonists in monoamine\u2010depleted rats, whereas the subthalamic nucleus, internal pallidal segment, and substantia nigra pars reticulata appear to be important for the effects of NMDA antagonists.<\/jats:p>","DOI":"10.1002\/ana.410280411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:27:34Z","timestamp":1104589654000},"page":"539-546","source":"Crossref","is-referenced-by-count":251,"title":["NMDA antagonists potentiate antiparkinsonian actions of <scp>L<\/scp>\u2010dopa in monoamine\u2010depleted rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Thomas","family":"Klockgether","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechoslaw","family":"Turski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5347-8_25"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90177-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90133-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5347-8_29"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90120-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235872"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720882.ch9"},{"key":"e_1_2_1_11_2","first-page":"1","article-title":"Dopamine\u2010GABA interactions: evidence that GABA transmits, modulates and mediates dopaminergic functions in the basal ganglia and the limbic system","volume":"107","author":"Scheel\u2010Kr\u00fcger J","year":"1986","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb07205.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90007-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_1_15_2","first-page":"1","article-title":"Efferent muscle innervation and rigidity","volume":"223","author":"Steg G","year":"1964","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01255820"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430020204"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01258633"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90007-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90123-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90384-1"},{"key":"e_1_2_1_22_2","first-page":"969","article-title":"MK\u2010801, a proposed non\u2010competitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine\u2010like behavioral effects in pigeons, rats and rhesus monkeys","volume":"245","author":"Koek W","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90754-1"},{"key":"e_1_2_1_24_2","first-page":"191","volume-title":"Current problems in epilepsy","author":"Troupin AS","year":"1986"},{"key":"e_1_2_1_25_2","first-page":"205","volume-title":"Excitatory amino acid transmission","author":"Woods JH","year":"1987"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/319774a0"},{"key":"e_1_2_1_27_2","first-page":"419","volume-title":"Frontiers in excitatory amino acid research","author":"Mondadori C","year":"1988"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90558-0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(89)90221-9"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.2.250"},{"key":"e_1_2_1_31_2","unstructured":"TurskiL BresslerK RettigK\u2010J et al.N\u2010methyl\u2010D\u2010aspartate antagonists protect substantia nigra from MPP+neurotoxicity. 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