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The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS) dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood\u2010brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. These results suggest that CSF neopterin, although not disease\u2010specific, may be useful as a surrogate marker for the presence of AIDS dementia complex and its response to antiviral therapy.<\/jats:p>","DOI":"10.1002\/ana.410280413","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:27:34Z","timestamp":1104589654000},"page":"556-560","source":"Crossref","is-referenced-by-count":128,"title":["Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection"],"prefix":"10.1002","volume":"28","author":[{"given":"Bruce J.","family":"Brew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi B.","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton K.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91203-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90111-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-784_2"},{"key":"e_1_2_1_5_2","first-page":"70","article-title":"Serum neopterin changes in HIV\u2010infected subjects: indicator of significant pathology, CD4 T cell changes and the development of AIDS","volume":"2","author":"Melmed RN","year":"1989","journal-title":"J Acq Immun Def Synd"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.5.1079"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-198905000-00006"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-198905000-00005"},{"key":"e_1_2_1_9_2","series-title":"Contemporary neurology series","first-page":"1","volume-title":"Advances in contemporary neurology","author":"Brew BJ","year":"1988"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.323"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90635-8"},{"key":"e_1_2_1_12_2","first-page":"76","article-title":"Intrathecal production of neopterin in aseptic meningoencephalitis and multiple sclerosis","volume":"67","author":"Fredrikson S","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.1.62"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1981.tb05536.x"},{"key":"e_1_2_1_15_2","first-page":"433","volume-title":"Biochemical and clinical aspects of pteridines","author":"Reibnegger G","year":"1984"},{"key":"e_1_2_1_16_2","first-page":"141","volume-title":"Chemistry and biology of pteridines","author":"Rokos K","year":"1983"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.830"},{"key":"e_1_2_1_18_2","unstructured":"HeyesMP BrewBJ MartinA et al.Quinolinic acid concentrations are increased in plasma and cerebrospinal fluid in AIDS and correlated with AIDS dementia complex. 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