{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:08:26Z","timestamp":1760980106694},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":5090,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is well recognized that plasma fluctuations resulting from oral levodopa therapy may cause an unstable clinical response in parkinsonian patients. We have therefore developed a slow\u2010release polymer matrix system that can deliver levodopa continuously for extended periods of time (at least 225 days) after subcutaneous implantation in rats. Advantages of this approach include (1) the elimination of levodopa plasma fluctuations and (2) the possibility of reducing the required dose due to constant plasma levels and because the gastrointestinal tract is circumvented. The peripheral implantation of polymer systems containing levodopa, dopamine receptor agonists, or other anti\u2010Parkinson agents may constitute a novel technology of drug delivery to improve the care of patients with Parkinson's disease.<\/jats:p>","DOI":"10.1002\/ana.410280519","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T11:53:40Z","timestamp":1104580420000},"page":"714-717","source":"Crossref","is-referenced-by-count":16,"title":["Extended levodopa release from a subcutaneously implanted polymer matrix in rats"],"prefix":"10.1002","volume":"28","author":[{"given":"B. A.","family":"Sabel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dominiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"H\u00e4user","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"During","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Freese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220406"},{"key":"e_1_2_1_3_2","first-page":"487","volume-title":"Pharmacokinetics of levodopa and motor fluctuations. Advances in Neurology, vol 45, Parkinson's Disease","author":"Hardie RJ","year":"1986"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.12.1144"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.487"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90442-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92929-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.2.233"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.9.1206"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000116171"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"CurzonG FriedelJ GrierL et al. Sustained\u2010release levodopa in Parkinsonism.Lancet1973:781","DOI":"10.1016\/S0140-6736(73)92182-X"},{"key":"e_1_2_1_12_2","first-page":"221","volume-title":"Recent Developments in Parkinson's Disease","author":"Latase X","year":"1987"},{"key":"e_1_2_1_13_2","first-page":"340","article-title":"Effect of a slow release preparation of levodopa on Parkinson's disease in combination with a peripheral decarboxylase inhibitor","volume":"58","author":"Saarien A","year":"1978","journal-title":"ActaNeurol Scand"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240116"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(89)90047-2"},{"key":"e_1_2_1_16_2","first-page":"43","article-title":"Inter\u2010laboratory comparison of plasma catecholamine determinations using several different assays","volume":"527","author":"Hjemdahl P","year":"1984","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250406"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410280519","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410280519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:34:35Z","timestamp":1697992475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410280519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1002\/ana.410280519"],"URL":"https:\/\/doi.org\/10.1002\/ana.410280519","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}