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Nine relatives with dystonia were identified in 6 families; 8 of these had symptoms such as clumsiness or tremor, but none were aware of any dystonia. A further 4 relatives, now deceased, were affected by history. Overall, 25% of index patients had relatives with dystonia. The results of segregation analysis suggested the presence of an autosomal dominant gene or genes with reduced penetrance as a common cause for focal dystonia. Segregation ratios were not significantly different from those ratios observed in generalized or segmental dystonia in the United Kingdom, and it is possible that a single autosomal dominant gene mutation is responsible for inherited dystonia in the majority of patients irrespective of distribution or severity.<\/jats:p>","DOI":"10.1002\/ana.410290315","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T11:57:02Z","timestamp":1104580622000},"page":"320-324","source":"Crossref","is-referenced-by-count":189,"title":["A genetic study of idiopathic focal dystonias"],"prefix":"10.1002","volume":"29","author":[{"given":"H. M.","family":"Waddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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