{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:27:35Z","timestamp":1764700055961},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4909,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been proposed that oxygen\u2010derived radicals, superoxide in particular, are involved in the alteration of blood\u2010brain barrier permeability and the pathogenesis of brain edema following trauma, ischemia, and reperfusion injury. Using transgenic mice that overexpress the human gene for copper\u2010zinc\u2010superoxide dismutase, we studied the role of superoxide radicals in the blood\u2010brain permeability changes, edema development, and delayed infarction resulting from cold\u2010trauma brain injury. At 2 hours after a 30\u2010second cold injury, cerebral water and Evans blue contents were reduced, respectively, from 80 \u00b1 0.2% and 132.7 \u00b1 12.9 m\u0308g\/gm of dry weight for nontransgenic mice to 78.5 \u00b1 0.3% and 87.1 \u00b1 9.9% m\u0308g\/gm of dry weight for transgenic mice. Infarction, as measured by 2,3,5\u2010triphenyltetrazolium chloride staining, was reduced by 52% in transgenic brains. These data indicate that an increased level of superoxide dismutase activity in the brain reduces the development of vasogenic brain edema and infarction. Superoxide radicals play an important role in the pathogenesis of these lesions in cold\u2010traumatized brain.<\/jats:p>","DOI":"10.1002\/ana.410290506","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:00:30Z","timestamp":1104580830000},"page":"482-486","source":"Crossref","is-referenced-by-count":173,"title":["Cold\u2010induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn\u2010Superoxide dismutase"],"prefix":"10.1002","volume":"29","author":[{"given":"P. H.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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Reduced glutamate neurotoxicity in transgenic mice overexpressing human CuZn\u2010superoxide dismutase. 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