{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:51:04Z","timestamp":1790059864400,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4848,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum concentrations of the cytokine interleukin\u20102 (IL\u20102) were quantitated by enzyme\u2010linked immunosorbent assay in 42 patients with Guillain\u2010Barr\u00e9 syndrome, 15 patients with chronic idiopathic demyelinating polyradiculoneuropathy, 37 patients with other neuropathies, 54 patients with other noninflammatory, nondemyelinating neurological disorders, and 26 healthy control subjects. We found markedly increased serum levels of IL\u20102 in patients with Guillain\u2010Barr\u00e9 syndrome and to a much lesser extent, in patients with chronic idiopathic demyelinating polyradiculoneuropathy. Increased serum concentrations of IL\u20102 in patients with Guillain\u2010Barr\u00e9 syndrome returned to normal in parallel with recovery from the disease. These findings suggest ongoing T\u2010cell proliferation in patients with Guillain\u2010Barr\u00e9 syndrome and some patients with chronic idiopathic demyelinating polyradiculoneuropathy. IL\u20102 levels were also raised in patients with active multiple sclerosis, myasthenia gravis, and herpes simplex encephalitis, and some patients with polymyositis, invoking T cells in the pathogenesis of these diseases.<\/jats:p>","DOI":"10.1002\/ana.410300110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:01:12Z","timestamp":1104580872000},"page":"48-53","source":"Crossref","is-referenced-by-count":129,"title":["Serum interleukin\u20102 concentrations in Guillain\u2010Barr\u00e9 syndrome and chronic idiopathic demyelinating polyradiculoneuropathy: Comparison with other neurological diseases of presumed immunopathogenesis"],"prefix":"10.1002","volume":"30","author":[{"given":"Hans\u2010Peter","family":"Hartung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Reiners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus 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