{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:05:22Z","timestamp":1780117522923,"version":"3.54.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4848,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoclonal proteins (IgM, IgG, and IgA) in the serum or urine of patients with neuropathy may provide a marker for amyloidosis, myeloma, lymphoma, leukemia, Waldenstr\u00f6m's macroglobulinemia, or monoclonal gammopathy of undetermined significance (MGUS). The clinical characteristics, course, and electromyographic features among neuropathies associated with monoclonal IgM (IgM\u2010MGUS, 31 patients), monoclonal IgG (IgG\u2010MGUS, 24 patients), and monoclonal IgA (IgA\u2010MGUS, 10 patients) evaluated between 1980 and 1986 were compared. Four statistically significant differences set IgM\u2010MGUS neuropathies apart from IgG\u2010MGUS and IgA\u2010MGUS neuropathies: (1) higher frequency of sensory loss and ataxia, (2) higher frequency of nerve conduction abnormality\u201410 attributes were significantly worse (none were significantly better), (3) higher frequency of dispersion of the compound muscle action potential, and (4) higher frequency of IgM\u2010MGUS in the MGUS neuropathy cohort than is characteristic of MGUS without neuropathy seen at our institution or than is encountered in epidemiological surveys. These differences were not thought to be due to selection or severity biases. Neither the amount of IgM nor the estimated size of the monoclonal peak was associated with severity of neuropathy. The type and severity of IgM\u2010MGUS neuropathies with anti\u2010myelin\u2010associated glycoprotein antibodies were not significantly different from those without anti\u2010myelin\u2010associated glycoprotein antibodies. A simple relationship between the presence and amount of IgM\u2010MGUS or anti\u2010myelin\u2010associated glycoprotein antibodies and neuropathy cannot be assumed.<\/jats:p>","DOI":"10.1002\/ana.410300111","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:01:12Z","timestamp":1104580872000},"page":"54-61","source":"Crossref","is-referenced-by-count":187,"title":["Neuropathy associated with monoclonal gammopathies of undetermined significance"],"prefix":"10.1002","volume":"30","author":[{"given":"Sylvie","family":"Gosselin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter James","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197507000-00001"},{"key":"e_1_2_1_3_2","first-page":"665","article-title":"Amyloidosis: clinical and laboratory features in 229 cases","volume":"58","author":"Kyle RA","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060102"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00490050038003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.24"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.2.202"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb14877.x"},{"key":"e_1_2_1_9_2","first-page":"543","article-title":"Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases","volume":"13","author":"Takatsuki K","year":"1983","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198007000-00006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.2.280.280"},{"key":"e_1_2_1_12_2","first-page":"93","article-title":"Les neuropathies p\u00e9riph\u00e9riques de la maladie de Waldenstr\u00f6m","volume":"20","author":"Vital C","year":"1975","journal-title":"Ann Anat Pathol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.00450050084010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.1.82"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00480040055005"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.1.42"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.1.75"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2065-4_4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90522-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/jama.1984.03340380031018","article-title":"\u2018Benign\u2019 monoclonal gammopathy\u2013a misnomer?","volume":"251","author":"Kyle RA","year":"1984","journal-title":"JAMA"},{"key":"e_1_2_1_21_2","first-page":"741","article-title":"Polyneuropathies a Rechotes dupuis 19 ans, associ\u00e9 a une gammapathie monoclonale IgG b\u00e9nign. 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