{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:59:00Z","timestamp":1791961140114,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4817,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eighty\u2010one patients with a first attack of isolated optic neuritis, 40 with Uhthoff's symptom (Group 1) and 41 without (Group 2), were studied. All had a neurovisual examination, 74 of 81 patients had the pattern visual evoked potential recorded at rest, and 43 had magnetic resonance imaging brain scans. The pattern visual evoked potential P100 latency was prolonged, Group 1 with a mean of 136 \u00b1 19 msec, Group 2 with a mean of 131 \u00b1 19 msec (control subjects, 102 \u00b1 5 msec; n = 84), and the P100 amplitude was reduced, without significant difference between the groups. Abnormal magnetic resonance imaging scans were present in significantly more patients in Group 1 (<jats:italic>P<\/jats:italic> &lt; 0.025). Treatment of optic neuritis with corticosteroids had no effect on the evolution or duration of Uhthoff's symptom. Overall, 35 of 81 (43%) patients, followed for a mean of 3.5 years, developed multiple sclerosis. The incidence was significantly greater in Group 1 (<jats:italic>p<\/jats:italic> &lt; 0.01). Uhthoff's symptom also correlated with a higher incidence of recurrent optic neuritis. We conclude that Uhthoff's symptom is a prognostic indicator for the early development of multiple sclerosis.<\/jats:p>","DOI":"10.1002\/ana.410300209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:02:15Z","timestamp":1104580935000},"page":"180-184","source":"Crossref","is-referenced-by-count":33,"title":["Uhthoff's symptom in optic neuritis: Relationship to magnetic resonance imaging and development of multiple sclerosis"],"prefix":"10.1002","volume":"30","author":[{"given":"Georgina Bates","family":"Scholl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu\u2010Shien","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley H.","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"303","article-title":"Untersuchungen \u00fcber die bei der multiplen Herdsklerose vorkommenden Augenst\u00f6rungen","volume":"21","author":"Uhthoff W","year":"1889","journal-title":"Arch Psychiatr Nervenkr"},{"key":"e_1_2_1_3_2","first-page":"385","article-title":"Uber das Uhthoffsche Symptom bei Multipler Sklerose","volume":"139","author":"Ricklefs G","year":"1961","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020040269011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1958.02340010049003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000050351002"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.1.60"},{"key":"e_1_2_1_8_2","first-page":"479","article-title":"Blurring of vision on exercise","volume":"86","author":"Thomson DS","year":"1966","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/01658108409053866"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.2.141"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90145-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.11.1083"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.3.250"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90131-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.2.369"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.6.723"},{"key":"e_1_2_1_17_2","unstructured":"SelhorstJB SaulRF WaybrightEA. 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