{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:42:38Z","timestamp":1698144158371},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4817,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies have not shown linkage of late\u2010onset (mean age, &gt;60 years) familial Alzheimer's disease (FAD) to the chromosome 21 locus reported linked to earlyonset FAD. Beta nerve growth factor (\u03b2\u2010NGF) has been considered a candidate gene in the pathogenesis and therapy of FAD, based on its localization in the cortex and hippocampus and its ability to enhance the growth and survival of cholinergic neurons. A 1.5\u2010kb fragment of the \u03b2\u2010NGF gene was used to detect a <jats:italic>Bgl<\/jats:italic> II restriction fragment length polymorphism, which was then used for linkage analysis. A total of 30 families (27 late onset) with 147 affected members were studied. Close linkage (\u03b8 &lt; 0.03, z &lt; \u22122.00) of late\u2010onset FAD with \u03b2\u2010NGF was excluded. Two apparent obligate crossovers between affected members were detected in different autopsy\u2010confirmed families. Based on these results, \u03b2\u2010NGF is not the gene responsible for late\u2010onset FAD in the families analyzed.<\/jats:p>","DOI":"10.1002\/ana.410300217","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:02:15Z","timestamp":1104580935000},"page":"216-219","source":"Crossref","is-referenced-by-count":4,"title":["Genetic linkage analysis of nerve growth factor (beta) in familial alzheimer's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Marchk J.","family":"Alberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Pericak\u2010Vance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernice","family":"Royal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Bebout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gaskell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Yen","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Earl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen D.","family":"Roses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90082-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90220-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780350019001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2880399"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91725-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3420406"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/347194a0"},{"key":"e_1_2_1_9_2","unstructured":"Pericak\u2010VanceM BeboutJ GaskellP et al. 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