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In addition, persistence of muscle tone by electromyographic criteria or excessive muscle twitching during REM sleep or both have been reported in treated and untreated narcoleptic patients. We report that another previously described abnormality of REM sleep, REM sleep behavior disorder, may also be a symptom of narcolepsy. This disorder was found in 10 narcoleptic patients during routine clinical evaluations involving polysomnography and multiple sleep latency tests. During REM sleep, 7 additional narcoleptic patients displayed persistent muscle tone and\/or excessive twitching, which we believe to be subclinical components of REM sleep behavior disorder. These 17 patients, diagnosed by established criteria for narcolepsy and for REM sleep behavior disorder, ranged in age from 8 to 74 years. Seventy\u2010one percent were male. Narcolepsy and REM sleep behavior disorder most commonly emerged in tandem. In 3 patients, treatment of narcolepsy\u2010cataplexy with stimulants and tricyclics either induced or exacerbated REM sleep behavior disorder.<\/jats:p>","DOI":"10.1002\/ana.410320103","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:15:39Z","timestamp":1104563739000},"page":"3-10","source":"Crossref","is-referenced-by-count":263,"title":["Motor dyscontrol in narcolepsy: Rapid\u2010eye\u2010movement (REM) sleep without atonia and REM sleep behavior disorder"],"prefix":"10.1002","volume":"32","author":[{"given":"Carlos H.","family":"Schenck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Mahowald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"338","volume-title":"Principles and practice of sleep medicine","author":"Guilleminault C","year":"1989"},{"key":"e_1_2_1_3_2","volume-title":"Chairman. 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