{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:03:05Z","timestamp":1791313385631,"version":"4.3.1"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,16]],"date-time":"2004-10-16T00:00:00Z","timestamp":1097884800000},"content-version":"vor","delay-in-days":4247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optic nerve and retinal gangliion cell (GC) degeneration are possible explanations for the poor visul function reported in patients with Alzheimer's disease (AD). We investigated whether GC loss could be attributed to AD compared with control subjects by measuring the spatial density of GC(vells\/mm<jats:sup>2<\/jats:sup>) with methods previously used to analyze the GC distribution of young normal retinas. Retinas from 4 autopsy\u2010confirmed, severely demented partients with AD and 4 age and sex\u2010matched control subjects (ages, 66\u201086 yr for both groups) withould history of dementing or ocular disease were prepared as unstained whold mounts. Therer was no evidence for loss of GC within the central 43 degrees of vision in patients with AD. The densityof GC subserving the central 11 degrees of vision was reduced by one\u2010fourth in both AD and control eyes compared with retinas from young adults, as was GC density in a wedge of nasal retina. This loss may contribute to deficits in visual function found in aged individuals, whether or not they have dementia.<\/jats:p>","DOI":"10.1002\/ana.410330305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:33:47Z","timestamp":1104590027000},"page":"248-257","source":"Crossref","is-referenced-by-count":235,"title":["Retinal ganglion cells in Alzheimer's disease and aging"],"prefix":"10.1002","volume":"33","author":[{"given":"Christine A.","family":"Curcio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Drucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604103141506"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(89)90127-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32769-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060070057015"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290110"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74985-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(87)90001-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7280699"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313742"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260207"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90288-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247137"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1437"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.1.309"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91173-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199003000-00008"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.3_Part_1.439"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-06-01799.1987"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00207459008986653"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433483"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1981.tb00080.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608213150804"},{"key":"e_1_2_1_24_2","first-page":"331","volume-title":"Vision and the brain","author":"Sadun AA","year":"1990"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32621-0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90653-7"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080020045040"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260208"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000103"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS\u2010ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"Mc Khann G","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(87)90137-4"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(89)90039-4"},{"key":"e_1_2_1_34_2","first-page":"691","article-title":"Ganglion cell loss in retinal whole\u2010mounts from patients with Alzheimer's disease","volume":"17","author":"Blanks JC","year":"1991","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_35_2","first-page":"356","article-title":"Ganglion cell loss in macula of patients with Alzheimer's disease","volume":"31","author":"Blanks JC","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_36_2","volume-title":"The retinal ganglion cell layer","author":"Van Buren A","year":"1963"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00577151"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902330403"},{"key":"e_1_2_1_39_2","first-page":"3","article-title":"The number of nerve fibers in the human optic nerve","volume":"61","author":"Arey LB","year":"1935","journal-title":"Anat Rec"},{"key":"e_1_2_1_40_2","first-page":"980","article-title":"Morphology of the primate optic nerve. 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