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For the initial 16 weeks, 40 subjects with mild to moderate AIDS dementia complex were randomized to one of three treatment arms: 400 mg of zidovudine five times daily, 200 mg of zidovudine five times daily, or placebo five times daily. After week 16, patients initially randomized to the placebo group were rerandomized to one of the two zidovudine treatment arms. The primary efficacy end point was improvement in performance on a battery of seven neuropsychological tests; the secondary end point was improvement on a protocol neurological evaluation directed at the cardinal features of the AIDS dementia complex. For the initial 16\u2010week period, average <jats:italic>z<\/jats:italic> scores based on the neuropsychological test battery revealed a significant improvement in the combined treatment groups compared to the placebo group; however, when the two treatment groups were compared separately to the placebo group, only the group receiving the higher zidovudine dose exhibited significant improvement. After rerandomization of the placebo patients to one of the two treatment arms at week 16, this group also showed significant improvement in the average neuropsychological <jats:italic>z<\/jats:italic> score by week 32. These results extend previous observations that indicate a therapeutic benefit of zidovudine for the treatment of AIDS dementia complex.<\/jats:p>","DOI":"10.1002\/ana.410330403","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:37:07Z","timestamp":1104572227000},"page":"343-349","source":"Crossref","is-referenced-by-count":206,"title":["Zidovudine treatment of the AIDS dementia complex: Results of a placebo\u2010controlled trial"],"prefix":"10.1002","volume":"33","author":[{"given":"John J.","family":"Sidtis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Gatsonis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse 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