{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:28:05Z","timestamp":1791080885698,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4208,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An increasing spectrum of diseases has been shown to be associated with the human T\u2010cell lymphotropic virus type I (HTLV\u2010I), most notably a chronic, progressive myelopathy termed HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis and adult T\u2010cell leukemia. HTLV\u2010II is a close relative of HTLV\u2010I and is structurally similar but molecularly distinct. This virus is endemic in Amerindian populations and a high seroprevalence rate has been observed in intravenous drug abusers. Here, for the first time, we have identified a patient with a chronic, progressive neurological disease clinically indistinguishable from HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis from whom we have isolated and characterized HTLV\u2010II in the absence of any other detectable human retrovirus. Antibodies to HTLV were deteced in both serum and cerebrospinal fluid, with typical HTLV\u2010II banding patterns on Western blots. HTLV\u2010II viral sequences were detected in high copy number from peripheral lymphocytes by polymerase chain reaction techniques, and cloning and sequencing of the virus revealed a 99.5% homology with prototype HTLV\u2010II. These results serve to alert the medical community to the possibility that in addition to HTLV\u2010I, HTLV\u2010II may be associated with a neurological disorder.<\/jats:p>","DOI":"10.1002\/ana.410330411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:37:07Z","timestamp":1104590227000},"page":"392-396","source":"Crossref","is-referenced-by-count":107,"title":["Isolation of HTLV\u2010II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis"],"prefix":"10.1002","volume":"33","author":[{"given":"Steven","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Lehky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale E.","family":"McFarlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhayl","family":"Dhib\u2010Jalbut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.22.7006"},{"key":"e_1_2_1_4_2","first-page":"372","article-title":"A second isolate of HTLV\u2010II associated with atypical hairy cell leukemia","volume":"313","author":"Rosenblatt JD","year":"1986","journal-title":"Science"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2655084"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8840"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.1.100"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270209"},{"key":"e_1_2_1_9_2","first-page":"325","volume-title":"PCR protocols","author":"Garth DE","year":"1990"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(86)90403-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93078-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.4.1057"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3101"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.1.85"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.197"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90797-7"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410330411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410330411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:02:37Z","timestamp":1698271357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410330411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/ana.410330411"],"URL":"https:\/\/doi.org\/10.1002\/ana.410330411","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}