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This peak disappeared with normalization of branched\u2010chain amino acids and oxoacids in the plasma and cerebrospinal fluid. In vitro spectroscopy of these metabolites at 1.5 T confirmed the chemical shift position of their methyl resonances at 1 ppm. The duration of lactate elevation correlated with the presence of brain edema and coma. These results demonstrate that magnetic resonance imaging can monitor therapeutic effects, and suggest that proton spectroscopy can detect cerebral accumulation of branched\u2010chain amino acids and oxoacids in maple syrup urine disease.<\/jats:p>","DOI":"10.1002\/ana.410330412","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:37:07Z","timestamp":1104590227000},"page":"396-401","source":"Crossref","is-referenced-by-count":63,"title":["Maple syrup urine disease: Metabolic decompensation monitored by proton magnetic resonance imaging and spectroscopy"],"prefix":"10.1002","volume":"33","author":[{"given":"S. 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