{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:52:42Z","timestamp":1784191962805,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4208,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell lymphotropic virus type one (HTLV\u20101) is associated with tropical spastic paraparesis or HTLV\u2010I\u2010associated myelopathy. We report 2 women with a spastic ataxic illness similar to HTLV\u2010I\u2010associated myelopathy infected solely with HTLV\u2010II. Identification of HTLV\u2010II infection was made serologically, by polymerase chain reaction, and by viral culture (in 1 woman). One woman, treated with 200 mg of danazol orally, three times daily, had pronounced improvement in ambulation, nocturnal spasticity, and nighttime urinary frequency. It appears that infection with HTLV\u2010II may cause an illness similar to HTLV\u2010I\u2010associated myelopathy, but distinguished by the presence of ataxia.<\/jats:p>","DOI":"10.1002\/ana.410330416","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:37:07Z","timestamp":1104590227000},"page":"411-414","source":"Crossref","is-referenced-by-count":86,"title":["Spastic ataxia associated with human T\u2010cell lymphotrophic virus type II infection"],"prefix":"10.1002","volume":"33","author":[{"suffix":"Jr","given":"William J.","family":"Harrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sheremata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brain","family":"Hjelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak K.","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K. H.","family":"Foung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Snodgrass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Toedter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Poiesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_3_2","first-page":"1096","article-title":"The risk of development of HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis among persons infected with HTLV\u2010I","volume":"3","author":"Kaplan JE","year":"1990","journal-title":"Acquired Immune Defic Syndr"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2655084"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1128\/jcm.28.4.646-650.1990","article-title":"Characterization of antibody reactivity to human T\u2010cell lymphotropic virus types I and II using immunoblot and radioimmunoprecipitation assays","volume":"28","author":"Hartley TM","year":"1990","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8840"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.1.85"},{"key":"e_1_2_1_9_2","unstructured":"RosenblattJD TomkinsP RosenthalM et al.Progressive spastic myelopathy in a patient co\u2010infected with HIV\u2010I and HTLV\u2010II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid. Presented at the Proceedings of the Fifth International Conference on Human Retrovirology HTLV Kumamoto Japan May 11\u201313 1992"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90797-7"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1991.7.1031"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1182\/blood.V79.10.2789.2789","article-title":"Cloning and analysis of a recombinant antigen containing an epitope specific for human T\u2010cell lymphotrophic virus type II","volume":"79","author":"Hadlock KG","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1992.8.527"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1182\/blood.V74.5.1658.1658","article-title":"Prevalence of human T\u2010cell leukemia\/lymphoma virus (HTLV) type II infection among high\u2010risk individuals: type\u2010specfic indentification of HTLVs by polymerase chain reaction","volume":"74","author":"Ehrlich GD","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.4.2456-2463.1992"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410330416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410330416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:02:47Z","timestamp":1698271367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410330416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/ana.410330416"],"URL":"https:\/\/doi.org\/10.1002\/ana.410330416","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}