{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:55:52Z","timestamp":1791255352985,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4178,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is now well established that clinically stable patients with relapsing\u2013remitting multiple sclerosis have ongoing disease activity when evaluated by serial gadolinium\u2013enhanced (Gd\u2010DTPA) magnetic resonance imaging (MRI) scans. Despite this, the relationship between clinical disease and MRI lesions, though suspected, has not been extensively documented. The relationship between Gd\u2010DTPA MRI lesions, and clinical disease was examined in this study of 9 patients with mild relapsing\u2013remitting multiple sclerosis (Expanded Disability Status Scale [EDSS] &lt;3.5) who had 24 to 37 monthly Gd\u2010DTPA MRI scans, neurological examinations, and EDSS score assignments. The area and frequency of Gd\u2010DTPA lesions were examined during months with and without clinical worsening as measured by EDSS. Forty\u2010one episodes of clinical worsening were noted during the study. A significant association was observed between these periods of clinical worsening and MRI parameters, including increases in total number, number of new lesions, and the total area of enhancement. Logistic regression analysis showed a signficant effect of the number and area of Gd\u2010DTPA MRI lesions on both the onset and continuation of clinical worsening, confirming an imporant relationship between clinical disease and an increase in cerebral Gd\u2010DTPA MRI activity. A relationship with long\u2010term disability was suggested, but cannot be confirmed without longer follow\u2010up of these patients.<\/jats:p>","DOI":"10.1002\/ana.410330511","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:09:39Z","timestamp":1104592179000},"page":"480-489","source":"Crossref","is-referenced-by-count":179,"title":["Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine\u2013enhancing magnetic resonance imaging lesions"],"prefix":"10.1002","volume":"33","author":[{"given":"M. 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