{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:45:18Z","timestamp":1774979118988,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":4086,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report 3 patients with autopsy\u2010proven Creutzfeldt\u2013Jakob disease who, early in their course, developed abnormal eye movements that included periodic alternating nystagmus and slow vertical saccades. These findings suggested involvement of the cerebellar nodulus and uvula, and the brainstem reticular formation, respectively. Cerebellar ataxia was also an early manifestation and, in 1 patient, a frontal lobe brain biopsy was normal at a time when ocular motor and cerebellar signs were conspicuous. As the disease progressed, all saccades and quick phases of nystagmus were lost, but periodic alternating gaze deviation persisted. At autopsy, 2 of the 3 patients had pronounced involvement of the cerebellum, especially of the midline structures. Creutzfeldt\u2010Jakob disease should be considered in patients with subacute progressive neurological disease when cognitive changes are overshadowed by ocular motor findings or ataxia.<\/jats:p>","DOI":"10.1002\/ana.410340215","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:24:54Z","timestamp":1104539094000},"page":"192-197","source":"Crossref","is-referenced-by-count":62,"title":["Abnormal eye movements in Creutzfeldt\u2013Jakob disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Michael P.","family":"Grant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Michael","family":"Halmagyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"McDougall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Tusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. John","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1675487"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195711142572005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080130070028"},{"key":"e_1_2_1_5_2","first-page":"133","article-title":"Subacute progressive encephalopathy with bulbar myoclonus","volume":"16","author":"Foley JF","year":"1957","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.28.4.350"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290058006"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312583"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90124-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.5.1323"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/352340a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90254-5"},{"key":"e_1_2_1_13_2","volume-title":"The neurology of eye movements","author":"Leigh RJ","year":"1991"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3871968"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb30906.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.5.1425"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016849"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080611"},{"key":"e_1_2_1_19_2","first-page":"191","article-title":"The association of period++ alternating nystagmus with periodic alternating gaze","volume":"1","author":"Kennard C","year":"1981","journal-title":"J Clin Neuro Ophthalmol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1740"},{"key":"e_1_2_1_21_2","first-page":"601","article-title":"Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloi++ plaques of Gerstmann\u2010Straussler syndrome, Creutzfeldt\u2010Jako++ disease and scrapie","volume":"63","author":"Snow AD","year":"1990","journal-title":"Lab Invest"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410340215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410340215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T08:38:24Z","timestamp":1698223104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410340215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1002\/ana.410340215"],"URL":"https:\/\/doi.org\/10.1002\/ana.410340215","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}