{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:30:37Z","timestamp":1770816637436,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3933,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain tissues from 6 patients with concentric sclerosis (Bal\u00f3) were examined by in situ hybridization, immunocytochemistry, morphometry, and histological methods. The patients were 24 to 48 years old and had progressive cerebral symptoms and signs that lasted 15 to 100 days. Large demyelinative lesions, most frequent in the frontal white matter, contained alternating bands of demyelinated and partly myelinated white matter that were arranged in concentric or mosaic patterns. In the areas of demyelination, axons were relatively well preserved and there were perivascular inflammatory infiltrates. In 2 specimens, lesions contained regions with the characteristic appearance of actively demyelinating multiple sclerosis plaques. Oligodendroglial densities were highest in normal\u2010appearing white matter, lower in partially myelinated areas, and lowest in demyelinated areas, which also contained many hypertrophic astrocytes closely associated with oligodendroglia. Messenger RNA levels for myelin\u2010related proteins followed the same pattern; they were lowest in demyelinated areas, higher in partially myelinated areas, and highest in normal\u2010appearing white matter beyond lesion margins. Our findings suggest that concentric sclerosis is a variant of multiple sclerosis, that oligodendroglial loss is important in the pathogenesis of demyelination, and that partially myelinated areas probably represent stages of ongoing myelin breakdown rather than remyelination of previously demyelinated areas.<\/jats:p>","DOI":"10.1002\/ana.410350105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:58:25Z","timestamp":1104595105000},"page":"18-30","source":"Crossref","is-referenced-by-count":74,"title":["Concentric sclerosis (Bal\u00f3): Morphometric and in situ hybridization study of lesions in six patients"],"prefix":"10.1002","volume":"35","author":[{"given":"Da\u2010Lin","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry deF.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn D.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo\u2010San","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso I.","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Komoly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"211","article-title":"Die sogenannte \u201cakute multiple sklerose\u201d (Enceph\u2010alomyelitis periaxialis scleroticans)","volume":"27","author":"Marburg O","year":"1906","journal-title":"J Psychiatr Neurol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1928.02210080044002"},{"key":"e_1_2_1_4_2","first-page":"437","volume-title":"Handbook of clinical neurology","author":"Courville CB","year":"1970"},{"key":"e_1_2_1_5_2","first-page":"491","article-title":"A case of primary form of progressive multifocal leukoencephalopathy with concentric demyelination of Bal\u00f3 type","volume":"15","author":"Markiewicz D","year":"1977","journal-title":"Neuropatol Pol"},{"key":"e_1_2_1_6_2","unstructured":"LiuD\u2010S LinS\u2010H RaoM\u2010L.Concentric sclerosis in Chinese.Norman Bethune University of Medical Sciences First Teaching Hospital Bull August1981;1\u201311"},{"key":"e_1_2_1_7_2","first-page":"67","article-title":"Concentric sclerosis","volume":"19","author":"Guo Y\u2010P","year":"1982","journal-title":"Proc Aust Assoc Neurol"},{"key":"e_1_2_1_8_2","first-page":"884","article-title":"Concentric sclerosis: report of a case with light and electron microscopic examination","volume":"95","author":"Guo Y\u2010P","year":"1982","journal-title":"Chin Med J"},{"key":"e_1_2_1_9_2","first-page":"417","article-title":"Bal\u00f3's concentric sclerosis\u2014a case report","volume":"36","author":"Chu ML","year":"1982","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"e_1_2_1_10_2","first-page":"299","article-title":"Clinical and pathological studies on ten cases of Bal\u00f3's concentric sclerosis","volume":"16","author":"Rao M\u2010L","year":"1983","journal-title":"Chin J Neurol Psychiatr"},{"key":"e_1_2_1_11_2","first-page":"479","article-title":"Scl\u00e9rose concentrique de Bal\u00f3","volume":"140","author":"Castaigne P","year":"1984","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_12_2","unstructured":"OrdinarioA TabiraT. Fifteen autopsied cases of concentric sclerosis (Bal\u00f3) seen in the Philippines.Int Center Med Res Ann1987;139\u2013148"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328514"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195701000-00007"},{"key":"e_1_2_1_15_2","first-page":"409","volume-title":"Handbook of clinical neurology","author":"Kuroiwa Y","year":"1985"},{"key":"e_1_2_1_16_2","first-page":"298","article-title":"Balo's concentric sclerosis: lesion distribution and histopathology","volume":"50","author":"Yao D\u2010L","year":"1991","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308816"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(86)90029-X"},{"key":"e_1_2_1_20_2","first-page":"39","volume-title":"In situ hybridization histochemistry","author":"Jordan CA","year":"1990"},{"key":"e_1_2_1_21_2","first-page":"95","volume-title":"In situ hybridization. Principles and practice","author":"Davenport AP","year":"1990"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/347103a0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01217922"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070212"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685250"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330203"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170614"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170511"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440020505"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1894"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/322544a0"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00733631"},{"key":"e_1_2_1_33_2","first-page":"624","article-title":"Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions","volume":"63","author":"Prineas JW","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199201000-00006"},{"key":"e_1_2_1_35_2","first-page":"88","article-title":"Multiple sclerosis: interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, nondemyelinating conditions","volume":"67","author":"Wu E","year":"1992","journal-title":"Lab Invest"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.9.845"},{"key":"e_1_2_1_37_2","first-page":"355","article-title":"Neuropathologic study of two cases of multiple sclerosis","volume":"94","author":"Guo Y\u2010P","year":"1981","journal-title":"Chin Med J"},{"key":"e_1_2_1_38_2","first-page":"273","volume-title":"Multiple sclerosis east and west","author":"Tabira T","year":"1982"},{"key":"e_1_2_1_39_2","first-page":"297","volume-title":"Multiple sclerosis east and west","author":"Ikuta F","year":"1982"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410350105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410350105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T18:23:03Z","timestamp":1698171783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410350105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/ana.410350105"],"URL":"https:\/\/doi.org\/10.1002\/ana.410350105","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}